Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy
Prognostic value of lymph node ratio in hypopharyngeal squamous cell carcinoma after chemoradiotherapy
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DOI：
10.3760/cma.j.issn.0366-6999.20131992
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发表时间：
2013-11-05
影响因子：
6.1
通讯作者：
Li Qing
中科院分区：
文献类型：
--
作者：
Yu Yue;Wang Xiao-lei;Li Qing
背景近年来，淋巴结比率(LNR)被认为是许多恶性疾病潜在的预后指标。我们旨在分析LNR对下咽鳞癌(HPSCC)新辅助治疗后的潜在预后影响。方法对1965年11月至2008年12月间279例下咽鳞状细胞癌(HPSCC)患者进行了回顾性研究，这些患者接受了放疗加化疗加颈淋巴清扫术。结果平均LNR为10.4%(范围0~100%，中位数4.3%)。男性和临床N分级明显增加(P=0.014和P<0.05)。
Background Lymph node ratio (LNR) has recently been reported as a potential prognostic marker in many malignant diseases. We aimed to analyze the potential prognostic effect of LNR on hypopharyngeal squamous cell carcinoma (HPSCC) after neoadjuvant therapy in our institution.Methods We performed a retrospective study of 279 patients with HPSCC who underwent radiotherapy with or without chemotherapy followed by neck dissection between November 1965 and December 2008. Patients were divided into four groups according to quartiles based on LNR.Results The mean LNR was 10.4% (range 0-100%, median 4.3%). Males and advanced clinical N classification significantly increased the LNR (P=0.014 and P