Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury.
Bone Morphogenetic Protein 4 Signalling in Neural Stem and Progenitor Cells during Development and after Injury.
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DOI：
10.1155/2016/9260592
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发表时间：
2016
影响因子：
4.3
通讯作者：
Xiao J
中科院分区：
文献类型：
--
作者：
Cole AE;Murray SS;Xiao J
在确定调节中枢神经系统（CNS）中神经干细胞和前体细胞生物学的细胞外信号通路方面已取得实质性进展。骨形态发生蛋白（BMP），特别是BMP 4，是调节胚胎、出生后和受损CNS中神经前体细胞发育为神经元和神经胶质细胞的关键参与者。在这里，我们回顾了最近的研究BMP 4信号在神经元，星形胶质细胞和少突胶质细胞的生成在中枢神经系统。我们还讨论了可能利用BMP 4影响CNS损伤后神经胶质细胞发育的机制，并强调了一些有待进一步研究的问题。
Substantial progress has been made in identifying the extracellular signalling pathways that regulate neural stem and precursor cell biology in the central nervous system (CNS). The bone morphogenetic proteins (BMPs), in particular BMP4, are key players regulating neuronal and glial cell development from neural precursor cells in the embryonic, postnatal, and injured CNS. Here we review recent studies on BMP4 signalling in the generation of neurons, astrocytes, and oligodendroglial cells in the CNS. We also discuss putative mechanisms that BMP4 may utilise to influence glial cell development following CNS injury and highlight some questions for further research.