Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome
Low free plasma levels of retinol-binding protein 4 in insulin-resistant subjects with polycystic ovary syndrome
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DOI：
10.1007/bf03345631
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发表时间：
2008-11
影响因子：
5.4
通讯作者：
E. Diamanti-Kandarakis;S. Livadas;S. A. Kandarakis;I. Papassotiriou;A. Margeli
中科院分区：
文献类型：
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作者：
E. Diamanti-Kandarakis;S. Livadas;S. A. Kandarakis;I. Papassotiriou;A. Margeli
背景：在动物和人类中已显示，脂肪组织产生的视黄醇结合蛋白 4 (RBP4) 会导致全身胰岛素抵抗 (IR)。循环 RBP4 的更敏感标记是 RBP4 与运甲状腺素蛋白 (TTR) 比率表达的游离血浆 RBP4，因为在循环中 RBP4 与 TTR 结合。目的：研究患有多囊卵巢综合征 (PCOS) 的胰岛素抵抗女性中的 RBP4 水平，并估计 RBP4/TTR 比率表达的游离血浆 RBP4。 受试者和方法：将 35 名 PCOS 受试者与年龄和体重指数匹配的 45 名对照进行比较（体重指数）。测定每位受试者的空腹血糖值、胰岛素、促性腺激素、雌二醇、雄激素、C 反应蛋白 (CRP)、RBP4 和 TTR。 结果：与对照组相比，PCOS 受试者的胰岛素抵抗程度更高 [IR 稳态模型评估 (HOMA-IR)：2.6± 0.3 与 1.9± 0.1，p=0.043]，并且 RBP4 水平较低（28.3±1.1 vs 32.4±1.2μg/ml，p=0.021）和RBP4/TTR比率（0.26±0.01 vs 0.31±0.01，p=0.0014）。当根据 BMI 状态（肥胖、超重和瘦受试者）对 RBP4 和 RBP4/TTR 值进行分层时，注意到瘦 PCOS 中的 RBP4 和 RBP4/TTR 值均显着低于对照组（RBP4：25.0± 5.5 vs 34.1± 9.0 μg/ml，p = 0.0063，RBP4/TTR：0.25± 0.3 vs 0.35±0.1，p=0.016）。没有观察到RBP4和RBP4/TTR与任何激素或代谢参数（包括BMI）之间的相关性。结论：与对照组相比，胰岛素抵抗PCOS受试者的RBP4和游离血浆RBP4（以RBP4/TTR比率表示）在统计学上显着较低。因此，我们的研究结果并未证实 IR 与 RBP4 或游离血浆 RBP4 水平之间存在联系。这些发现的意义仍有待阐明，因为与其他脂肪因子一样，RBP4 可能被证明对人类和啮齿动物具有不同的作用。
Background: It has been shown in animals and in humans that retinol-binding protein 4 (RBP4) production from adipose tissue leads to generalized insulin resistance (IR). A more sensitive marker of circulating RBP4 is free plasma RBP4 expressed by RBP4 to transthyretin (TTR) ratio, since in circulation RBP4 is bound to TTR.Aim: To investigate RBP4 levels in insulin-resistant women with polycystic ovary syndrome (PCOS) and to estimate free plasma RBP4 expressed by RBP4/TTR ratio.Subjects and methods: Thirty-five PCOS subjects were compared with 45 controls matched for age and body mass index (BMI). In each subject, fasting values of glucose, insulin, gonadotropins, estradiol, androgens, C-reactive protein (CRP), RBP4, and TTR were determined.Results: PCOS subjects in comparison to controls were more insulin-resistant [homeostasis model assessment for IR (HOMA-IR): 2.6± 0.3 vs 1.9± 0.1,p=0.043], and presented lower RBP4 levels (28.3± 1.1 vs 32.4± 1.2 μg/ml,p=0.021) and RBP4/TTR ratio (0.26± 0.01 vs 0.31± 0.01,p=0.0014). When RBP4 and RBP4/TTR values where stratified according to BMI status (obese, overweight, and lean subjects), it was noticed that both RBP4 and RBP4/TTR values in lean PCOS were significantly lower than in controls (RBP4: 25.0± 5.5 vs 34.1± 9.0 μg/ml,p=0.0063, RBP4/TTR: 0.25± 0.3 vs 0.35± 0.1,p=0.016). No correlation was observed between RBP4 and RBP4/TTR with any hormonal or metabolic parameter including BMI.Conclusions: RBP4 and free plasma RBP4 expressed as RBP4/TTR ratio are statistically and significantly lower in insulin-resistant PCOS subjects in comparison to controls. Therefore, our findings do not confirm a link between IR, neither with RBP4 nor with free plasma RBP4 levels. The significance of these findings remains to be elucidated, since RBP4 might prove to have different actions, like other adipokines, from humans and rodents.