Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation.
Activation of NMDA receptors increases brain-derived neurotrophic factor (BDNF) mRNA expression in the hippocampal formation.
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NMDA 受体的激活会增加海马结构中脑源性神经营养因子 (BDNF) mRNA 的表达。
DOI：
10.1097/00001756-199311180-00007
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发表时间：
1993
期刊：
影响因子：
1.7
通讯作者：
Springer,JE
中科院分区：
文献类型：
--
作者：
Gwag,BJ;Springer,JE
在本研究中，NMDA 受体的激活可上调齿状回和 CA3 锥体神经元颗粒细胞中的脑源性神经营养因子 (BDNF)。颗粒细胞中的 BDNF mRNA 水平在 4 小时内达到峰值，24 小时仍然明显，并在 48 小时内恢复到对照水平。在 CA3 区域，BDNF mRNA 水平在 NMDA 处理后 2 小时显着增加，4 小时达到峰值，并在 8 小时恢复到对照值。最后，NMDA 对 BDNF mRNA 表达的影响被 NMDA 受体拮抗剂 AP5 阻断。这些发现证明 NMDA 受体的体内激活可能调节这种神经营养蛋白的表达。
IN the present study, it is demonstrated that activation of NMDA receptors upregulates brain-derived neurotrophic factor (BDNF) in granule cells of the dentate gyrus and CA3 pyramidal neurons. BDNF mRNA levels in the granule cells peaked within 4 h, were still evident at 24 h, and returned to control levels within 48 h. In the CA3 region, BDNF mRNA levels were significantly increased at 2 h, peaked at 4 h, and returned to control values by 8 h following NMDA treatment. Finally, the effects of NMDA on BDNF mRNA expression were blocked by AP5, an NMDA receptor antagonist. These findings provide evidence that the in vivo activation of NMDA receptors may regulate the expression of this neurotrophin.