Type I and III collagen degradation products in serum predict patient survival in head and neck squamous cell carcinoma
Type I and III collagen degradation products in serum predict patient survival in head and neck squamous cell carcinoma
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DOI：
10.1016/j.oraloncology.2011.09.002
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发表时间：
2012-02-01
期刊：
影响因子：
4.8
通讯作者：
Risteli, Juha
中科院分区：
文献类型：
--
作者：
Nurmenniemi, Sini;Koivula, Marja-Kaisa;Risteli, Juha
肿瘤侵袭诱导细胞外基质重塑和胶原降解。本研究的目的是评估血清I型和III型胶原降解产物水平是否与头颈部鳞状细胞癌（HNSCC）患者的生存率相关。建立了一种测定人血清中Ⅲ型胶原N端肽（IIINTP）的酶免疫分析方法。此外，I型胶原C-末端肽（ICTP），基质金属蛋白酶-8（MMP-8）和金属蛋白酶组织抑制剂-1（TIMP-1）进行了评估，在205例血液样本从HNSCC患者。高水平的血清ICTP和IIINTP以及血浆TIMP-1与生存率低相关。ICTP浓度与IIINTP和TIMP-1水平相关。MMP-8的血浆浓度与肿瘤分期相关，但与ICTP、IIINTP或TIMP-1的存活率或水平无关，这表明其他胶原酶/蛋白酶负责I型和III型胶原的切割。I型和III型胶原降解率与患者生存率相关，可用作HNSCC的预后标志物。(C)2011爱思唯尔有限公司保留所有权利。
Cancer invasion induces extracellular matrix remodeling and collagen degradation. The aim of this study was to assess whether serum levels of type I and III collagen degradation products were associated with patient survival in head and neck squamous cell carcinoma (HNSCC). A novel enzyme immunoassay was developed for measuring type III collagen N-terminal telopeptide (IIINTP) in human serum samples. In addition, type I collagen C-terminal telopeptide (ICTP), matrix metalloprotease-8 (MMP-8) and tissue inhibitor of metalloproteases-1 (TIMP-1) were assessed in 205 blood samples from HNSCC patients. High levels of serum ICTP and IIINTP and plasma TIMP-1 were associated with poor survival. The concentration of ICTP was associated with levels of IIINTP and TIMP-1. The plasma concentration of MMP-8 was associated with tumor stage, but not with survival or levels of ICTP, IIINTP or TIMP-1 suggesting that other collagenases/proteases are responsible for the cleavage of type I and type III collagens. The rate of type I and type III collagen degradation is associated with patient survival and can be used as a prognostic marker in HNSCC. (C) 2011 Elsevier Ltd. All rights reserved.