Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
Spatio-temporal control of cellular uptake achieved by photoswitchable cell-penetrating peptides
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DOI：
10.1039/c5cc06848g
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发表时间：
2016-01-01
影响因子：
4.9
通讯作者：
Moeller, Heiko M.
中科院分区：
文献类型：
--
作者：
Prestel, Andreas;Moeller, Heiko M.
选择性地将化合物吸收到特定的细胞中是细胞生物学和药物传递的一个主要目标。通过结合一种新型的、耐热的偶氮苯片段，我们生成的肽可以在非活性状态和活性状态之间进行光学切换，具有良好的时空控制。
The selective uptake of compounds into specific cells of interest is a major objective in cell biology and drug delivery. By incorporation of a novel, thermostable azobenzene moiety we generated peptides that can be switched optically between an inactive state and an active, cell-penetrating state with excellent spatio-temporal control.