COORDINATE REGULATION AND SENSORY TRANSDUCTION IN THE CONTROL OF BACTERIAL VIRULENCE
COORDINATE REGULATION AND SENSORY TRANSDUCTION IN THE CONTROL OF BACTERIAL VIRULENCE
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DOI：
10.1126/science.2537530
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发表时间：
1989-02-17
期刊：
影响因子：
56.9
通讯作者：
FALKOW, S
中科院分区：
文献类型：
--
作者：
MILLER, JF;MEKALANOS, JJ;FALKOW, S
编码细菌毒力因子的基因和操纵子通常受到协调调控。这些调节系统能够对感染周期中可能遇到的各种环境信号做出反应。对于某些病原体，介导感觉转导和毒力控制的蛋白质与其他细菌信息处理系统的组成部分相似。了解致病性全球调控的分子机制对于了解细菌传染病至关重要。
Genes and operons that encode bacterial virulence factors are often subject to coordinate regulation. These regulatory systems are capable of responding to various environmental signals that may be encountered during the infectious cycle. For some pathogens, proteins that mediate sensory transduction and virulence control are similar to components of other bacterial information processing systems. Understanding the molecular mechanisms governing global regulation of pathogenicity is essential for understanding bacterial infectious diseases.