DETECTION OF AUTOIMMUNITY PARAMETERS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (aids)
DETECTION OF AUTOIMMUNITY PARAMETERS IN THE ACQUIRED IMMUNODEFICIENCY SYNDROME (aids)
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获得性免疫缺陷综合症（艾滋病）中自身免疫参数的检测
DOI：
10.1111/j.1365-4362.1992.tb03250.x
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发表时间：
1992
影响因子：
3.6
通讯作者：
J. Stratigos
中科院分区：
文献类型：
--
作者：
K. Kyriakis;A. Tosca;J. Katsantonis;M. Hatzivasiliou;G. Eliopoulos;J. Stratigos
我们检查了艾滋病的各种自身免疫参数，特别强调天疱疮和大疱性类天疱疮抗体的表达。研究了健康无梅毒血清阳性个体（cs -, n = 17）、梅毒血清阳性个体（cs+, n = 11）和艾滋病患者（n = 6）的血清，并与正常对照（n = 30）进行了比较；评估与皮肤病学相关的自身免疫参数。对天疱疮和类天疱疮抗体、抗核抗体（ANA）、抗DNA抗体、抗平滑肌抗体（ASMA）、抗线粒体抗体（AMA）和抗甲状腺抗体（ATA）进行间接免疫荧光（IIF）检测，并对每组患者的结果用累积指数（ci）进行分级。33%的艾滋病患者检测到天疱疮和大疱性类天疱疮样抗体（IgG, PV+BP）。与cs+组相比，cs−组ci增高（P<0.01），与cs−组相比，AIDS组ci增高（P<0.01）。
We have examined various autoimmunity parameters in AIDS with special emphasis on the expression of pemphigus and bullous pemphigoid antibodies. Sera from healthy seropositive individuals without syphilis (cs−, n = 17), seropositive individuals with syphilis (cs+, n = 11), and patients with AIDS (n = 6) were studied and compared with normal controls (n = 30); autoimmunity parameters related to dermatology were evaluated. Indirect immunofluorescence (IIF) for pemphigus and pemphigoid antibodies, antinuclear antibodies (ANA), anti‐DNA antibodies, antismooth muscle antibodies (ASMA) antimitochondrial antibodies (AMA), and antithyroid antibodies (ATA) was carried out and findings were graded with a cumulative index (ci) for each patient group. Pemphigus and bullous pemphigoid‐like antibodies (IgG, PV+BP) were detected in 33% of the AIDS patients. Statistically increased ci (P<0.01) was found in the cs− group compared with the cs+ group and in the AIDS group compared with cs− (P<0.01).