SOLID-PHASE SYNTHESIS OF CECROPIN-A AND RELATED PEPTIDES
SOLID-PHASE SYNTHESIS OF CECROPIN-A AND RELATED PEPTIDES
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DOI：
10.1073/pnas.80.21.6475
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发表时间：
1983-01-01
期刊：
影响因子：
--
通讯作者：
BOMAN, HG
中科院分区：
文献类型：
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作者：
ANDREU, D;MERRIFIELD, RB;BOMAN, HG
Cecropin A, a 37-residue antibacterial peptide amide, was synthetized by the solid-phase method. It was shown to be homogeneous and totally indistinguishable from natural cecropin A [from the Cecropia moth] by chemical and physical criteria and by its antibacterial activity against several gram-positive and gram-negative organisms. The synthetic material was also used to establish unambiguously that the carboxyl terminal blocking group of natural cecropin A is a primary amide as tentatively proposed earlier. The role of the amino terminus of cecropin A in antibacterial activity was investigated by the synthesis of 2 analogs.
