Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003
Extended interhuman transmission of monkeypox in a hospital community in the Republic of the Congo, 2003
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DOI：
10.4269/ajtmh.2005.73.428
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发表时间：
2005-08-01
影响因子：
3.3
通讯作者：
Damon, IK
中科院分区：
文献类型：
--
作者：
Learned, LA;Reynolds, MG;Damon, IK
本报告描述了刚果共和国首次报告的人猴痘疫情。在这次暴发期间，观察到11例确诊和可能的猴痘病例，所有病例均不到18岁，大多数居住在Implondo政府医院。分子，病毒学，血清学和诊断检测用于检测猴痘（或正痘）病毒感染的证据，在个人与显着的皮肤病和其他临床表现。这次暴发中的大多数病例都患有严重的症状性疾病;有一人死亡，可能涉及继发性并发症，还有一例严重后遗症。据推测，猴痘病毒在人与人之间的连续传播多达六次，这是迄今为止有充分记录的人类猴痘病毒最长的不间断链。在这次疫情期间观察到的持续人际传播模式可能会影响我们目前对这种人畜共患病病毒适应人类能力的看法。
This report describes the first reported outbreak of human monkeypox in the Republic of Congo. Eleven confirmed and probable monkeypox cases were observed during this outbreak, all were less than 18 years old, and most resided on the grounds of the Government Hospital in Implondo. Molecular, virologic, and serologic, and diagnostic assays were used to detect evidence of monkeypox (or orthopox) virus infection in individuals with striking dermatologic and other clinical manifestations. The majority of cases in this outbreak experienced significant, symptomatic illnesses; there was one death, possibly involving secondary complications, and one instance of profound sequelae. Up to six sequential transmissions of monkeypox virus from person to person are hypothesized to have occurred, making this the longest uninterrupted chain of human monkeypox fully documented to date. The pattern of sustained human-to-human transmission observed during this outbreak may influence our current perception of the capacity for this zoonotic virus to adapt to humans.