Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events: The MESA (Multi-Ethnic Study of Atherosclerosis).
Aortic Arch Pulse Wave Velocity Assessed by Magnetic Resonance Imaging as a Predictor of Incident Cardiovascular Events: The MESA (Multi-Ethnic Study of Atherosclerosis).
复制标题
DOI：
10.1161/hypertensionaha.116.08749
复制
发表时间：
2017-09
期刊：
影响因子：
--
通讯作者：
Lima JAC
中科院分区：
文献类型：
--
作者：
Ohyama Y;Ambale-Venkatesh B;Noda C;Kim JY;Tanami Y;Teixido-Tura G;Chugh AR;Redheuil A;Liu CY;Wu CO;Hundley WG;Bluemke DA;Guallar E;Lima JAC
磁共振成像(MRI)评估的主动脉弓脉搏波速度(PWV)对心血管疾病(CVD)事件的预测价值尚未完全确立。本研究的目的是评估ARCH PWV与MESA发生的心血管事件的相关性。用MRI测量了3527名无明显心血管疾病的MESA参与者(基线平均年龄为62±10岁，其中47%为男性)的主动脉弓PWV。经年龄、性别、种族和心血管病危险因素调整后，使用Cox回归分析来评估心血管事件(冠心病、中风、短暂性脑缺血发作或心力衰竭)与ARCH PWV的关系。ARCH PWV的中位数为7.4(IQR5.6~10.2)m/S。ARCH PWV与年龄有显著的交互作用，因此按年龄分组(45-54岁和54岁以上)进行分析。在10年的随访中，有456例心血管事件。45-54岁的受试者ARCH PWV与心血管事件的发生独立于心血管危险因素(HR，1.44；95%可信区间：1.07-1.95；p=0.018；对数转换后的PWV每1SD增加)，而54岁以上的受试者无显著关联(p=0.93)。在中年(45-54岁)人群中，MRI评估的主动脉弓PWV是心血管事件的重要预测因子，而在多民族人群中，ARCH PWV与老年心血管疾病无关。
The predictive value of aortic arch pulse wave velocity (PWV) assessed by magnetic resonance imaging (MRI) for cardiovascular disease (CVD) events has not been fully established. The aim of the present study was to evaluate the association of arch PWV with incident CVD events in MESA. Aortic arch PWV was measured using MRI at baseline in 3,527 MESA participants (mean age = 62 ± 10 years at baseline, 47% male) free of overt CVD. Cox regression was used to evaluate the risk of incident CVD (coronary heart disease, stroke, transient ischemic attack, or heart failure) in relation to arch PWV adjusted for age, gender, race, and CVD risk factors. The median value of arch PWV was 7.4 (IQR; 5.6 to 10.2) m/s. There was significant interaction between arch PWV and age for outcomes, so analysis was stratified by age categories (45–54 and over 54 years). There were 456 CVD events over the 10-year follow-up. 45–54 year-old participants had significant association of arch PWV with incident CVD independent of CVD risk factors (HR, 1.44; 95% confidence interval, 1.07 to 1.95; p=0.018; per 1SD increase for logarithmically transformed PWV), whereas over 54 years group did not (p=0.93). Aortic arch PWV assessed by MRI is a significant predictor of CVD events among middle-aged (45 to 54 years old) individuals, whereas arch PWV is not associated with CVD among an elderly in a large multi-ethnic population.