PROGNOSTIC IMPLICATIONS OF P53 NUCLEAR OVEREXPRESSION AND HIGH PROLIFERATION INDEX OF KI-67 IN ADULT SOFT-TISSUE SARCOMAS
PROGNOSTIC IMPLICATIONS OF P53 NUCLEAR OVEREXPRESSION AND HIGH PROLIFERATION INDEX OF KI-67 IN ADULT SOFT-TISSUE SARCOMAS
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DOI：
10.1093/jnci/86.7.549
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发表时间：
1994-04-06
期刊：
影响因子：
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通讯作者：
CORDONCARDO, C
中科院分区：
文献类型：
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作者：
DROBNJAK, M;LATRES, E;CORDONCARDO, C
背景资料：形态相似的软组织肉瘤可能表现出非常不同的方式，使得难以预测临床结果和适当设计治疗干预措施。在一项初步研究中，我们观察到TP 53突变和p53蛋白的核过表达是软组织肉瘤中的常见事件，我们注意到p53阳性表型和不良临床结局之间的关联。目的：我们研究了p53过度表达在成人软组织肉瘤中的潜在临床意义。我们还研究了高增殖指数的临床意义。研究方法：采用抗p53和抗Ki-67抗体和免疫组化方法对174例成人软组织肉瘤患者的新鲜冷冻组织样本进行分析。结果：我们观察到p53核过度表达与肿瘤分级（P = 0.001）和肿瘤大小（P = 0.01）之间存在显著相关性。显示p53阳性表型的患者生存率显著降低（P = 0.02）。同样，高增殖指数与肿瘤分级之间也存在显著差异（P
Background: Morphologically similar soft-tissue sarcomas may behave in very different fashions, making it difficult to predict clinical outcomes and to properly design therapeutic interventions. In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical outcome. Purpose: We examined the potential clinical relevance of p53 overexpression in adults with soft-tissue sarcomas. We also studied the clinical implications of a high proliferation index. Methods: A cohort of 174 adults with soft-tissue sarcomas were analyzed using anti-p53 and anti-Ki-67 antibodies and immunohistochemical assays on consecutive fresh frozen tissue samples. Results: We observed a significant association between p53 nuclear overexpression and tumor grade (P = .001) and tumor size (P = .01). Patients displaying a p53-positive phenotype had significantly reduced survival (P = .02). Similarly, a significant difference was observed between high proliferation index and tumor grade (P