Skin pentosidine and telomere length do not covary with age in a long-lived seabird
Skin pentosidine and telomere length do not covary with age in a long-lived seabird
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DOI：
10.1007/s10522-015-9564-1
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发表时间：
2015-08-01
期刊：
影响因子：
4.5
通讯作者：
Horak, Peeter
中科院分区：
文献类型：
--
作者：
Rattiste, Kalev;Klandorf, Hillar;Horak, Peeter
关于自然界中衰老为什么以及如何发生的问题是进化生态学中最相关的问题之一。端粒长度是一种常用的衰老标志物，而其他衰老生物标志物却很少受到关注。在这里，我们研究了另一个有效的老化指标皮肤戊糖浓度与年龄和血液端粒长度的关系，在一个长寿的海鸟与记录良好的生殖衰老。我们没有发现端粒长度之间的关联，皮肤pentosidine和实足年龄的雄性普通海鸥（Larus canus），年龄从2到30年。然而，端粒长度的变化是4.6倍，年龄超过13岁的鸟类，这暗示了在已经过了繁殖的黄金年龄的鸟类中对端粒长度的放松选择。这些结果表明，生理年龄和实足年龄可能在很大程度上解耦在我们的研究系统。此外，我们的研究结果不支持关于存在共同生理因素的假设（例如，例如氧化应激），这将导致两个独立的衰老标记之间的共变。
The questions about why and how senescence occurs in the wild are among the most pertinent ones in evolutionary ecology. Telomere length is a commonly used marker for aging, while other biomarkers of aging have received considerably less attention. Here we studied how another potent indicator of aging-skin pentosidine concentration-relates to age and blood telomere length in a long-lived seabird with well-documented reproductive senescence. We found no associations between telomere length, skin pentosidine and chronological age in male common gulls (Larus canus), aging from 2 to 30 years. However, the variance in telomere length was 4.6 times higher among the birds older than 13 years, which hints at relaxed selection on telomere length among the birds that have passed their prime age of reproduction. These results suggest that physiological and chronological ages may be largely uncoupled in our study system. Furthermore, our findings do not support a hypothesis about the presence of a common physiological factor (e.g., such as oxidative stress) that would cause covariation between two independent markers of aging.