Survey of the Prognosis for Dermatomyositis, with Special Reference to Its Association with Malignancy and Pulmonary Fibrosis
Survey of the Prognosis for Dermatomyositis, with Special Reference to Its Association with Malignancy and Pulmonary Fibrosis
复制标题
皮肌炎的预后调查，特别是其与恶性肿瘤和肺纤维化的关系
DOI：
10.1111/j.1346-8138.1986.tb02935.x
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Rika Kikuchi
中科院分区：
文献类型：
--
作者：
A. Hidano;K. Kaneko;Y. Arai;Rika Kikuchi
我们向日本主要的皮肤病机构发送了关于皮肌炎（DM）的病程和相关性的问卷。在1973年至1983年观察到的637例病例中，68例是儿童。儿童死亡率为2.9%，成年男性为47.1%，成年女性为30.0%。在30.1%的成人中发现与恶性肿瘤相关; 112例（19.7%的成人）死于这些疾病，但手术改善了22例患者的DM体征。主要肿瘤为胃癌、肺癌、结肠癌和乳腺癌。在85例（14.9%的成人）中观察到与肺纤维化（PF）相关，尽管进行了强化治疗，仍有38例（6.7%）死于PF，大多数在2个月内死亡的PF病例在DM发病后6个月内开始出现肺部症状。DM发病前发生PF者全部存活。PF和恶性肿瘤的并发症是例外。仅3例死于心肌疾病。
We sent questionnaires to the major dermatological institutions in Japan concerning the course and associations of dermatomyositis (DM). Of 637 cases observed between 1973 and 1983, 68 were children. The mortality rate was 2.9% in children, 47.1% in adult males, and 30.0% in adult females. Associations with malignancies were noted in 30.1% of adults; 112 cases (19.7% of adults) died from these, but surgery improved the signs of DM in 22 cases. The main neoplasms were cancer of the stomach, lung, colon, and breast. Association with pulmonary fibrosis (PF) was observed in 85 cases (14.9% of adults) and, in spite of intensive treatment, 38 cases (6.7%) died from it. In the majority of PF cases who died within 2 months, pulmonary symptoms started within 6 months of the onset of DM. All cases of PF which occurred before the onset of DM survived. The concurrence of PF and malignancies was exceptional. Death from myocardial disease occurred in only 3 cases.