Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils
Clinical outcome of tonsillectomy for palmoplantar pustulosis and etiological relationship between palmoplantar pustulosis and tonsils
复制标题
扁桃体切除术治疗掌跖脓疱病的临床效果及掌跖脓疱病与扁桃体的病因关系
DOI：
10.1159/000324618
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Takahara M
中科院分区：
文献类型：
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作者：
Shiga K;Ogawa T;Maki A;Amano M;Kobayashi T.;Takahara M
掌跖脓疱病（PPP）是一种典型的扁桃体局灶性疾病。通过主观自我评估，116例患者中有109例（94%）在扁桃体切除术后PPP皮疹临床改善，通过客观掌跖脓疱病面积和严重程度指数（PPPASI）评分，59例患者中有52例（88%）在扁桃体切除术后PPP皮疹临床改善。流式细胞术分析显示，活化标志物（CD 25和HLA）II类的表达增加扁桃体T细胞从PPP和IgAN患者。此外，皮肤归巢受体（CLA和CCR 6）的表达增加扁桃体T细胞从PPP患者。此外，土著细菌的刺激增强了表达。此外，这些表达也在外周血T细胞中增加，并且在扁桃体切除术后减少。免疫组织化学分析显示，这些受体的配体（E-选择素和趋化因子配体20）在皮肤病变中表达。在我们的研究结果的基础上，扁桃体T细胞上的几个归巢受体表达对土著细菌的超免疫反应的迁移在扁桃体局灶性疾病的发病机制中起着至关重要的作用。
Palmoplantar pustulosis (PPP) is famous for causing typical tonsillar focal diseases. Clinical improvement of PPP rash after tonsillectomy was seen in 109 (94%) of 116 patients by subjective self-assessment, and 52 (88%) of 59 patients by objective Palmoplantar Pustulosis Area and Severity Index (PPPASI) scoring. Flow-cytometric analyses revealed that expression of activation markers (CD25 and HLA) class II increased on tonsillar T cells from PPP and IgAN patients. Moreover, expressions of skin-homing receptors (CLA and CCR6) increased on tonsillar T cells from PPP patients. In addition, the expressions were enhanced by stimulation of indigenous bacteria. Moreover, those expressions also increased in peripheral T cells, and decreased after tonsillectomy. Immunohistchemical analyses revealed that the ligands of those receptors (E-selectin and chemokine ligand 20) were expressed in lesions of skin. On the basis of our findings, migration of tonsillar T cells on which several homing receptors express by hyperimmune response against indigenous bacteria have a critical role in the pathogenesis of tonsillar focal diseases.