Circadian rhythms in mitochondrial respiration.
Circadian rhythms in mitochondrial respiration.
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DOI：
10.1530/jme-17-0196
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发表时间：
2018-04
影响因子：
3.5
通讯作者：
Kalsbeek A
中科院分区：
文献类型：
--
作者：
de Goede P;Wefers J;Brombacher EC;Schrauwen P;Kalsbeek A
许多生理过程以24小时为周期进行调节，以预测白天到夜间的环境变化，反之亦然。这些24小时的规则，通常被称为昼夜节律，除其他外，控制着睡眠-觉醒周期，运动活动和在活动阶段（人类白天，夜行动物夜间）准备食物。社会时差或轮班工作扰乱了器官或全身的昼夜节律，增加了患慢性代谢疾病（如2型糖尿病）的风险。这种风险的分子基础是一个日益引起人们兴趣的话题。线粒体是真核生物产生大部分能量的重要细胞器，通过氧化磷酸化将脂质和碳水化合物转化为ATP。为了适应不断变化的环境，线粒体在形式和功能上都是高度动态的，这种灵活性的丧失与代谢疾病有关。有趣的是，最近的研究表明，线粒体形态的变化（即融合和裂变）以及新线粒体的产生依赖于可行的昼夜节律钟。此外，裂变和聚变过程显示与光/暗周期一致的日变化。除了形态变化外，线粒体呼吸也表现出日变化。在动物模型中干扰分子钟会导致线粒体节律性丧失和呼吸改变。此外，线粒体依赖的活性氧的产生在细胞信号传导中起作用，也与生物钟有关。在这篇综述中，我们将总结线粒体昼夜节律的研究进展及其与分子生物钟的联系。
Many physiological processes are regulated with a 24-h periodicity to anticipate the environmental changes of daytime to nighttime and vice versa. These 24-h regulations, commonly termed circadian rhythms, among others control the sleep–wake cycle, locomotor activity and preparation for food availability during the active phase (daytime for humans and nighttime for nocturnal animals). Disturbing circadian rhythms at the organ or whole-body level by social jetlag or shift work, increases the risk to develop chronic metabolic diseases such as type 2 diabetes mellitus. The molecular basis of this risk is a topic of increasing interest. Mitochondria are essential organelles that produce the majority of energy in eukaryotes by converting lipids and carbohydrates into ATP through oxidative phosphorylation. To adapt to the ever-changing environment, mitochondria are highly dynamic in form and function and a loss of this flexibility is linked to metabolic diseases. Interestingly, recent studies have indicated that changes in mitochondrial morphology (i.e., fusion and fission) as well as generation of new mitochondria are dependent on a viable circadian clock. In addition, fission and fusion processes display diurnal changes that are aligned to the light/darkness cycle. Besides morphological changes, mitochondrial respiration also displays diurnal changes. Disturbing the molecular clock in animal models leads to abrogated mitochondrial rhythmicity and altered respiration. Moreover, mitochondrial-dependent production of reactive oxygen species, which plays a role in cellular signaling, has also been linked to the circadian clock. In this review, we will summarize recent advances in the study of circadian rhythms of mitochondria and how this is linked to the molecular circadian clock.