Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy
Genetic characterization of tick-borne flaviviruses: New insights into evolution, pathogenetic determinants and taxonomy
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DOI：
10.1016/j.virol.2006.09.015
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发表时间：
2007-04-25
期刊：
影响因子：
3.7
通讯作者：
de Lamballerie, Xavier
中科院分区：
文献类型：
--
作者：
Grard, Gilda;Moureau, Gregory;de Lamballerie, Xavier
在这里，我们分析了所有公认的蜱传黄病毒物种的完整编码序列，包括小工具沟皇家农场和Karshi病毒，海鸟相关的黄病毒，Kadant病毒和以前未知的分离物的Kyasanur森林病病毒和鄂木斯克出血热病毒。提出了重大的分类学改进，例如确定三个主要类别（哺乳动物，海鸟和卡丹蜱传黄病毒组），创建一个新的物种（Karshi病毒）以及森林脑炎病毒和Louping病病毒归属于一个独特种（蜱传脑炎病毒），包括四种病毒类型（即西部蜱传脑炎病毒、东部蜱传脑炎病毒、土耳其绵羊蜱传脑炎病毒和Louping病蜱传脑炎病毒）。分析还表明，感染鸟类的病毒与感染哺乳动物的病毒之间存在复杂的关系。以这两类脊椎动物为食的蜱虫可能构成了这三个不同的谱系之间的进化桥梁。(c)D 2006 Elsevier Inc. All rights reserved.
Here, we analyze the complete coding sequences of all recognized tick-borne flavivirus species, including Gadgets Gully Royal Farm and Karshi virus, seabird-associated flaviviruses, Kadant virus and previously uncharacterized isolates of Kyasanur Forest disease virus and Omsk hemorrhagic fever virus. Significant taxonomic improvements are proposed, e.g. the identification of three major groups (mammalian, seabird and Kadam tick-borne flavivirus groups), the creation of a new species (Karshi virus) and the assignment of Tick-borne encephalitis and Louping ill viruses to a unique species (Tick-borne encephalitis virus) including four viral types (i.e. Western Tick-borne encephalitis virus, Eastern Tick-borne encephalitis virus, Turkish sheep Tick-borne encephalitis virus and Louping ill Tick-borne encephalitis virus). The analyses also suggest a complex relationship between viruses infecting birds and those infecting mammals. Ticks that feed on both categories of vertebrates may constitute the evolutionary bridge between the three distinct identified lineages. (c) D 2006 Elsevier Inc. All rights reserved.