Cardiac sympathetic denervation preceding motor signs in Parkinson disease
Cardiac sympathetic denervation preceding motor signs in Parkinson disease
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DOI：
10.1007/s10286-007-0396-1
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发表时间：
2007-04-01
影响因子：
5.8
通讯作者：
Eisenhofer, Graeme
中科院分区：
文献类型：
--
作者：
Goldstein, David S.;Sharabi, Yehonatan;Eisenhofer, Graeme
人们对识别生物标志物以检测早期帕金森病(PD)有很大兴趣。新发帕金森病患者心脏去甲肾上腺素能神经支配和压力感受性反射-心脏迷走神经功能减弱，但这些异常是否先于帕金森病尚不清楚。我们在此报告一例患者，在帕金森病症状和体征出现4年前，左室心肌6-[F-18]氟多巴胺衍生的放射性和低压力感受性心脏迷走神经增益显著降低。这些结果使我们推测，心脏去甲肾上腺素能神经支配和压力感受性反射-心脏迷走神经功能降低可能在帕金森病发病的早期发生。
There is substantial interest in identifying biomarkers to detect early Parkinson disease (PD). Cardiac noradrenergic denervation and attenuated baroreflex-cardiovagal function occur in de novo PD, but whether these abnormalities can precede PD has been unknown. Here we report the case of a patient who had profoundly decreased left ventricular myocardial 6-[F-18]fluorodopamine-derived radioactivity and low baroreflex-cardiovagal gain, 4 years before the onset of symptoms and signs of PD. The results lead us to hypothesize that cardiac noradrenergic denervation and decreased baroreflex-cardiovagal function may occur early in the pathogenesis of PD.