Developmental predisposition to cancer
Developmental predisposition to cancer
复制标题
DOI：
10.1038/422494a
复制
发表时间：
2003-04-03
期刊：
影响因子：
64.8
通讯作者：
Nowak, MA
中科院分区：
文献类型：
--
作者：
Frank, SA;Nowak, MA
许多人类癌症发生在更新的上皮组织中，其中细胞谱系通常经历两个不同的阶段：在生命早期，细胞群以指数方式扩张以形成组织，并且在生命的剩余时间，组织通过干细胞分裂而更新，以创建几乎线性的细胞历史。在这里，我们使用一个简单的数学模型来表明，在指数阶段出现的突变可能会给组织带来携带突变的干细胞，这些突变可能会导致癌症。因此，对晚期癌症（如皮肤癌和结肠癌）的易感性可能受到早期发育期间发生的体细胞突变的影响。
Many human cancers occur in renewing epithelial tissues, in which cellular lineages typically go through two distinct phases: early in life, cell populations expand exponentially to form the tissue, and for the remainder of life, the tissue is renewed by stem cells dividing to create an almost linear cellular history. Here we use a simple mathematical model to show that mutations that arise during the exponential phase probably seed tissues with stem cells carrying mutations that may predispose to cancer. Susceptibility to late-life cancers, such as those of the skin and colon, may therefore be influenced by somatic mutations that occur during early development.