Monoamines and Spinal Reflexes
Monoamines and Spinal Reflexes
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单胺和脊髓反射
DOI：
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发表时间：
1965
期刊：
影响因子：
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通讯作者：
A. Lundberg
中科院分区：
文献类型：
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作者：
A. Lundberg
已有许多报道表明单胺类物质影响脊髓中的传递。全身给予肾上腺素（A）和去甲肾上腺素（NA）可能对脊髓反射产生促进和抑制作用（参考文献见McLennan 1963，第84页），但由于这些儿茶酚胺很可能不会穿透血脑屏障，因此这些作用可能继发于循环变化。同样的间接作用可能也适用于全身注射5-羟色胺（5-HT）的实验。已经发现在脊髓上局部应用单胺的一些效果（参见图1）。McLennan 1963），但Curtis、Phillis和Watkins（1961）发现腹腔注射NA和5-HT对该组织中的单个细胞无影响。
There have been many reports that monoamines influence transmission in the spinal cord. Systemic administration of adrenaline (A) and noradrenaline (NA) may give both facilitatory and inhibitory effects on spinal reflexes (for references see McLennan 1963, p. 84) but since these catecholamines in all likelihood do not penetrate the blood brain barrier it is possible that the effects are secondary to circulatory changes. The same indirect action probably also applies to experiments with systemic injection of 5-hydroxytryptamine (5-HT). Some effects have been found with topical application of monoamines on the spinal cord (cf. McLennan 1963), but Curtis, Phillis and Watkins (1961) found no effect of electrophoretically administered NA and 5-HT on single cells in this tissue.