Infrared imaging of sub-retinal structures in the human ocular fundus
Infrared imaging of sub-retinal structures in the human ocular fundus
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DOI：
10.1016/0042-6989(95)00100-e
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发表时间：
1996-01-01
期刊：
影响因子：
1.8
通讯作者：
Delori, FC
中科院分区：
文献类型：
--
作者：
Elsner, AE;Burns, SA;Delori, FC
在体内研究了红外光与人眼底，特别是视网膜下结构的相互作用。使用可见光和红外波长以及扫描激光检眼镜来获取人体眼底的数字图像。针对一系列成像波长或模式计算选定的视网膜和视网膜下特征的对比度和反射率。对于视网膜下特征，近红外光比可见光提供更好的可见度。视网膜下沉积物显得较轻且增厚；视神经乳头、视网膜血管和脉络膜血管呈黑色。随着波长从 795 纳米增加到 895 纳米，特征的对比度和可见度也随之增加。优化成像模式可以提高某些结构的可见度。这种近红外成像技术的新定量基础可应用于广泛的成像模式，用于研究影响视网膜色素上皮和布鲁赫膜的疾病（例如年龄相关性黄斑变性）的病理生理学和治疗。
The interaction of infrared light with the human ocular fundus, particularly sub-retinal structures, was studied in vivo. Visible and infra-red wavelengths and a scanning laser ophthalmoscope were used to acquire digital images of the human fundus. The contrast and reflectance of selected retinal and sub-retinal features were computed for a series of wavelengths or modes of imaging. Near infrared light provides better visibility than visible light for sub-retinal features. Sub-retinal deposits appear light and thickened; the optic nerve head, retinal vessels, and choroidal vessels appear dark. Contrast and visibility of features increases with increasing wavelength from 795 to 895 nm. Optimizing the mode of imaging improves the visibility of some structures. This new quantitative basis for near infrared imaging techniques can be applied to a wide range of imaging modalities for the study of pathophysiology and treatment in diseases affecting the retinal pigment epithelium and Bruch's membrane, such as age-related macular degeneration.