Prognostic Significance of Combined Platelet Distribution Width and C-Reactive Protein Score in Esophageal Cancer
Prognostic Significance of Combined Platelet Distribution Width and C-Reactive Protein Score in Esophageal Cancer
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DOI：
10.21873/anticanres.14586
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发表时间：
2020-10-01
影响因子：
2
通讯作者：
Minamiya, Yoshihiro
中科院分区：
文献类型：
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作者：
Kawakita, Yuta;Motoyama, Satoru;Minamiya, Yoshihiro
背景/目标：血小板分布宽度（PDW）和血清C反应蛋白（CRP）水平是已知的各种恶性肿瘤的预后预测。我们的目的是确定结合PDW和血清CRP水平是否产生食管癌（EC）患者的预后指标。患者和方法：共有168例食管癌患者在食管切除术前接受了新辅助治疗。结果如下：我们将PDW和CRP（CPC）联合评分定义如下：治疗前PDW均较低（≥ 0.5 mg/dl）的患者评分为2分，而其中一项或两项均不存在的患者评分为1分或0分。多变量分析显示，CPC评分是总体（p = 0.006）和无复发（p = 0.004）生存率的显著风险因素。结论：CPC评分是食管癌患者的一个强有力的预后指标。
Background/Aim: The platelet distribution width (PDW) and serum C-reactive protein (CRP) levels are known to be predictive of prognosis in various malignancies. Our aim was to determine whether combining PDW and serum CRP levels produces a prognostic indicator for esophageal cancer (EC) patients. Patients and Methods: A total of 168 EC patients who underwent neoadjuvant therapy prior to esophagectomy were included in this study. Results: We defined a combined PDW and CRP (CPC) score as follows: patients with both low pretherapeutic PDW (= 0.5 mg/dl) were assigned a score of 2, while patients with one or neither of those were assigned a score of 1 or 0. A multivariable analysis showed that the CPC score was a significant risk factor for overall (p=0.006) and recurrence-free (p=0.004) survival. Conclusion: The CPC score is a strong prognostic indicator in EC patients.