Clofibrate does not alter cyclic nucleotide metabolism in muscle.
Clofibrate does not alter cyclic nucleotide metabolism in muscle.
复制标题
氯贝特不会改变肌肉中的环核苷酸代谢。
DOI：
10.1016/0026-0495(83)90222-6
复制
发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Levey,GS
中科院分区：
文献类型：
--
作者：
Lehotay,DC;Paul,HS;Gindler,JS;Adibi,SA;Levey,GS
氯贝丁酯是一种降血脂药，可导致大鼠肌肉蛋白分解和人类急性肌肉综合症。它还抑制脂肪组织中的腺苷酸环化酶。肌肉蛋白质代谢已被证明受环核苷酸调节。在本实验中，我们测量了环核苷酸代谢的几个参数，以确定环核苷酸在安妥明诱导的肌肉蛋白降解中所起的作用。研究发现，安妥明治疗不会改变环核苷酸水平，也不会改变肌肉中基础或激素刺激的腺苷酸环化酶或环核苷酸磷酸二酯酶的活性。我们的结果表明，氯贝特治疗大鼠的肌肉蛋白分解不受环核苷酸的调节。
Clofibrate is a hypolipidemic agent that causes muscle protein breakdown in rats, and an acute muscular syndrome in man. It also inhibits adenylate cyclase in fat tissue. Muscle protein metabolism has been shown to be regulated by cyclic nucleotides. In the present experiments we measured several parameters of cyclic nucleotide metabolism to determine the role that cyclic nucleotides play in clofibrate-induced muscle protein degradation. It was found that clofibrate treatment did not alter cyclic nucleotide levels, nor did it change the activities of basal or hormone-stimulated adenylate cyclase, or cyclic nucleotide phosphodiesterase in muscle. Our results suggest that muscle protein breakdown in clofibrate-treated rats is not regulated by cyclic nucleotides.