THE POLYMORPHIC SUBTELOMERIC REGIONS OF PLASMODIUM-FALCIPARUM CHROMOSOMES CONTAIN ARRAYS OF REPETITIVE SEQUENCE ELEMENTS
THE POLYMORPHIC SUBTELOMERIC REGIONS OF PLASMODIUM-FALCIPARUM CHROMOSOMES CONTAIN ARRAYS OF REPETITIVE SEQUENCE ELEMENTS
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DOI：
10.1073/pnas.91.2.619
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发表时间：
1994-01-18
影响因子：
11.1
通讯作者：
RAVETCH, JV
中科院分区：
文献类型：
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作者：
DEBRUIN, D;LANZER, M;RAVETCH, JV
人类疟原虫恶性疟原虫表现出高度的染色体多态性，这可能有助于其逃避宿主防御的能力。对寄生虫染色体的分析表明，这些多态性仅限于亚端粒区域，该区域转录沉默并包含重复序列元件。使用恶性疟原虫酵母人工染色体 (YAC) 克隆分离并绘制了几个亚端粒重复元件。寄生虫端粒和亚端粒 YAC 克隆的结构分析表明，这些重复元件在恶性疟原虫染色体末端之间是保守的。我们认为这些亚端粒元件促进恶性疟原虫中的染色体配对，并促进减数分裂重组和端粒近端基因之间的基因转换。
The human malaria parasite Plasmodium falciparum exhibits a high degree of chromosomal polymorphism, which may contribute to its ability to evade host defenses. The analysis of parasite chromosomes has revealed that these poly morphisms are confined to the subtelomeric regions, which are transcriptionally silent and contain repetitive sequence elements. Several subtelomeric repetitive elements have been isolated and mapped by using P. falciparum yeast artificial chromosome (YAC) clones. Structural analysis of parasite telomeric and subtelomeric YAC clones demonstrated that these repetitive elements are conserved between P. falciparum chromosome ends. We suggest that these subtelomeric elements promote chromosome pairing in P. falciparum and facilitate meiotic recombination and gene conversion between telomere-proximal genes.