Fat-induced satiety factor oleoylethanolamide enhances memory consolidation
Fat-induced satiety factor oleoylethanolamide enhances memory consolidation
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DOI：
10.1073/pnas.0903038106
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发表时间：
2009-05-12
影响因子：
11.1
通讯作者：
Piomelli, Daniele
中科院分区：
文献类型：
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作者：
Campolongo, Patrizia;Roozendaal, Benno;Piomelli, Daniele
记住与令人厌恶和有益的经历相关的背景的能力为在野外觅食的动物提供了明显的适应优势。目前的实验研究是否在喂养过程中释放的激素信号可能会增强最近经历的上下文信息的记忆。油酰乙醇胺（OEA）是一种内源性脂质介质，当膳食脂肪进入小肠时释放。OEA通过在肠道中参与α型过氧化物酶体增殖物激活受体（PPAR-alpha）并招募迷走神经的局部传入神经来介导脂肪诱导的饱腹感。在这里，我们表明，OEA在大鼠训练后管理改善保留在抑制性回避和Morris水迷宫任务。这些作用被利多卡因注入孤束核（NTS）和普萘洛尔注入杏仁核基底外侧复合体（BLA）所阻断。这些结果表明，OEA产生的记忆增强信号通过传入自主神经纤维激活大脑，并刺激BLA中的去甲肾上腺素能传递。OEA的作用被PPAR-alpha激动剂模拟，并在缺乏PPAR-alpha的突变小鼠中被消除。结果表明，OEA，作为一种PPAR-alpha激动剂，促进记忆巩固通过去甲肾上腺素激活的BLA，一种机制，也是关键参与记忆增强诱导的情绪唤醒。
The ability to remember contexts associated with aversive and rewarding experiences provides a clear adaptive advantage to animals foraging in the wild. The present experiments investigated whether hormonal signals released during feeding might enhance memory of recently experienced contextual information. Oleoylethanolamide (OEA) is an endogenous lipid mediator that is released when dietary fat enters the small intestine. OEA mediates fat-induced satiety by engaging type-alpha peroxisome proliferator-activated receptors (PPAR-alpha) in the gut and recruiting local afferents of the vagus nerve. Here we show that post-training administration of OEA in rats improves retention in the inhibitory avoidance and Morris water maze tasks. These effects are blocked by infusions of lidocaine into the nucleus tractus solitarii (NTS) and by propranolol infused into the basolateral complex of the amygdala (BLA). These findings suggest that the memory-enhancing signal generated by OEA activates the brain via afferent autonomic fibers and stimulates noradrenergic transmission in the BLA. The actions of OEA are mimicked by PPAR-alpha agonists and abolished in mutant mice lacking PPAR-alpha. The results indicate that OEA, acting as a PPAR-alpha agonist, facilitates memory consolidation through noradrenergic activation of the BLA, a mechanism that is also critically involved in memory enhancement induced by emotional arousal.