Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy
Recent advances in understanding apoptosis: new therapeutic opportunities in cancer chemotherapy
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DOI：
10.1016/s1471-4914(03)00084-4
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发表时间：
2003-06-01
影响因子：
13.6
通讯作者：
Dive, C
中科院分区：
文献类型：
--
作者：
Makin, G;Dive, C
在体外对细胞凋亡分子机制的调控方面，我们已经取得了重大进展。在健康细胞中，将增殖和凋亡联系在一起的分子正在被识别，在这里，凋亡性细胞死亡提供了“故障安全”机制，以抵消过度增殖。最近，在肿瘤发展的动物模型中关于细胞凋亡调控的开创性工作表明，在存在增殖刺激的情况下抑制细胞凋亡足以促进肿瘤的发展。在阐明药物诱导的细胞凋亡对肿瘤反应的贡献方面也取得了进展。随着越来越多的证据表明，药物治疗后未能参与细胞凋亡导致体内耐药，人们重新相信，基于细胞凋亡途径中药物靶点的新治疗方法将改善癌症患者的治疗。一如既往，肿瘤的特异性是需要解决的主要问题。
Major advances have been made in our understanding of the regulation of the molecular machinery of apoptosis in vitro. Molecules linking proliferation and apoptosis in healthy cells are being identified and here apoptotic cell death provides the 'fail-safe' mechanism to counteract excess proliferation. More recently, pioneering work on the regulation of apoptosis, in animal models of tumour development, has shown that suppression of apoptosis in the presence of a proliferative stimulus is sufficient for tumour development. Progress has also been made towards clarifying the contribution of drug-induced apoptosis to tumour response. With increasing evidence that failure to engage apoptosis after drug treatment contributes to drug resistance in vivo comes renewed confidence that new therapeutic approaches based on drug targets in apoptotic pathways will improve the treatment of cancer patients. As ever, tumour specificity is the major issue to be resolved.