Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver
Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver
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DOI：
10.1016/s0006-8993(00)02423-9
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发表时间：
2000-07-14
期刊：
影响因子：
2.9
通讯作者：
Buijs, RM
中科院分区：
文献类型：
--
作者：
la Fleur, SE;Kalsbeek, A;Buijs, RM
下丘脑视交叉上核负责大鼠基础葡萄糖水平的24小时节律。视交叉上核用于调节血糖节律的神经通路尚未确定。在本研究中，我们检查了下丘脑中心（包括视交叉上核）与肝脏（葡萄糖产生和储存的主要场所）之间是否存在任何联系。肝脏跨神经元病毒示踪显示，注射伪狂犬病病毒后，中枢神经系统中特定的神经元细胞群被逆行标记，表明中枢神经系统中的特定位点可能控制肝脏代谢。一级神经元属于交感和副交感神经系统，而二级和三级神经元存在于脑干和下丘脑。第三级神经元的存在下，在视交叉上核表明参与生物钟的神经控制的肝脏。(C)2000 Elsevier Science BN。All rights reserved.
The suprachiasmatic nucleus of the hypothalamus is responsible for a 24-h rhythm in basal glucose levels in the rat. The neural pathways used by the suprachiasmatic nucleus to mediate this rhythm in plasma glucose have not yet been identified. In the present study we examined whether there are any connections between hypothalamic centers, including the suprachiasmatic nucleus, and the liver, which is the main site for glucose production and storage. Transneuronal virus tracing from the liver showed that after injection of pseudorabies virus, specific neuronal cell populations in the central nervous system were labeled retrogradely, suggesting that specific sites in the central nervous system may control liver metabolism. First-order neurons belonged to the sympathetic and parasympathetic system, while second-order and third-order neurons were present in both the brainstem and hypothalamus. The presence of third-order neurons in the suprachiasmatic nucleus suggests an involvement of the biological clock in the neural control of the liver. (C) 2000 Elsevier Science BN. All rights reserved.