Central corneal thickness as a risk factor for advanced glaucoma damage
Central corneal thickness as a risk factor for advanced glaucoma damage
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DOI：
10.1001/archopht.122.1.17
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发表时间：
2004-01-01
影响因子：
--
通讯作者：
Stinnett, SS
中科院分区：
文献类型：
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作者：
Herndon, LW;Weizer, JS;Stinnett, SS
目的：为了确定中央角膜厚度（CCT）是否与青光眼的严重程度有关，在最初的examination.Methods：首次访问青光眼专科连续原发性开角型青光眼患者从1997年至2002年进行了回顾性分析。对每位患者的年龄、性别、种族、青光眼家族史、青光眼药物治疗次数、视力、等效球镜、眼压、CCT、视野数据以及垂直和水平杯盘比进行分析。中央角膜厚度显着低于黑人（平均值，537 μ m）比白人（平均值，556 μ m）。较低的CCT与晚期青光眼干预研究评分恶化、视野平均偏差恶化、垂直和水平杯盘比增加以及青光眼药物治疗数量增加显著相关。在多变量分析中，较低的CCT与恶化的晚期青光眼干预研究评分，恶化的平均偏差视野，并增加垂直和水平杯盘ratio.Conclusions：中央角膜厚度是一个强大的临床因素，在确定青光眼的严重程度在最初的检查由专家。测量CCT可以帮助眼科医生识别进展风险高的青光眼患者。
Objective: To determine if central corneal thickness (CCT) is related to the level of glaucoma severity at the initial examination.Methods: The initial visit to a glaucoma specialist by consecutive patients with primary open-angle glaucoma from 1997 to 2002 was reviewed retrospectively. Each patient's age, sex, race, family history of glaucoma, number of glaucoma medications, visual acuity, spherical equivalent, intraocular pressure, CCT, visual field data, and vertical and horizontal cup-disc ratios were analyzed.Results: Three hundred fifty eyes of 190 patients met the inclusion and exclusion criteria. Central corneal thickness was significantly lower in blacks (mean, 537 mum) than in whites (mean, 556 pm). Lower CCT was significantly associated with worsened Advanced Glaucoma Intervention Study score, worsened mean deviation of visual field, increased vertical and horizontal cup-disc ratios, and increased number of glaucoma medications. In multivariate analysis, lower CCT was significantly associated with worsened Advanced Glaucoma Intervention Study score, worsened mean deviation of visual field, and increased vertical and horizontal cup-disc ratios.Conclusions: Central corneal thickness is a powerful clinical factor in determining glaucoma severity at the initial examination by a specialist. Measuring CCT may aid the ophthalmologist in identification of glaucoma patients at high risk for progression.