Seasonal variation in the risk of ischemic stroke in patients with atrial fibrillation: A nationwide cohort study
Seasonal variation in the risk of ischemic stroke in patients with atrial fibrillation: A nationwide cohort study
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DOI：
10.1016/j.hrthm.2018.06.043
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发表时间：
2018-11-01
期刊：
影响因子：
5.5
通讯作者：
Chen, Shih-Ann
中科院分区：
文献类型：
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作者：
Liao, Jo-Nan;Chao, Tze-Fan;Chen, Shih-Ann
研究背景：几种心血管疾病具有季节性变化，但关于寒冷温度与心房颤动（AF）患者缺血性卒中风险的数据有限。目的本研究的目的是探讨不同季节缺血性卒中的风险，检验寒冷季节会增加房颤患者中风风险的假设。方法本研究使用国家健康保险研究数据库，台湾从2000年至2012年，共入组了289，559例AF患者，平均随访3年后，34，991例发生缺血性卒中。结果缺血性脑卒中发病率以冬季最高，发病率为0.33/100人月。与夏季相比，春季缺血性脑卒中发病风险增加100/（发病率比[IRR] 1.10; 95%置信区间[CI] 1.07-1.13），冬季减少19%（IRR 1.19; 95% CI 1.15-1.22），但夏季和秋季之间无显著差异（IRR 1.00; 95% CI 0.97-1.03）。与平均气温30摄氏度的日子相比，平均气温30摄氏度的日子发生缺血性中风的风险
BACKGROUND Several cardiovascular diseases exhibit seasonal variations, but data about cold temperature and risk of ischemic stroke in patients with atrial fibrillation (AF) are limited.OBJECTIVE The purpose of this study was to investigate the risk of ischemic stroke in different seasons, testing the hypothesis that the cold weather season would increase the risk of stroke in AF.METHODS This study used the National Health Insurance Research Database in Taiwan. From 2000 to 2012, a total of 289,559 AF patients were enrolled, and 34,991 experienced ischemic stroke after mean follow-up of 3 years. The relationship between risk of ischemic stroke and temperatures was analyzed.RESULTS The highest incidence of ischemic stroke was observed in winter, which was the coldest season, with an incidence rate of 0.33 per 100 person-months. Compared with the summer period, the risk of ischemic stroke increased by 10 0 /0 in spring (incidence rate ratio [IRR] 1.10; 95% confidence interval [CI] 1.07-1.13) and by 19% in winter (IRR 1.19; 95% CI 1.15-1.22) but did not differ significantly between summer and autumn (IRR 1.00; 95% CI 0.97-1.03). Compared with the days with an average temperature of 30 degrees C, the risk of ischemic stroke for days with an average temperature