A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy
A randomised placebo-controlled trial of ursodeoxycholic acid and S-adenosylmethionine in the treatment of intrahepatic cholestasis of pregnancy
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DOI：
10.1111/j.1471-0528.1998.tb09976.x
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发表时间：
1998-11-01
期刊：
影响因子：
--
通讯作者：
Fanelli, M
中科院分区：
文献类型：
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作者：
Nicastri, PL;Diaferia, A;Fanelli, M
在32例妊娠期肝内胆汁淤积症患者中进行了一项随机安慰剂对照研究。人群被分为四组：每组仅用熊去氧胆酸或S-腺苷甲硫氨酸或两种药物的组合或安慰剂（维生素）治疗20天。治疗前、治疗中和治疗后分别测量瘙痒、标准肝功能检查和血清总胆汁酸。所有女性的瘙痒和生化异常都有所改善。治疗期间和治疗后，母亲或婴儿均未出现副作用。熊去氧胆酸和S-腺苷甲硫氨酸的组合比安慰剂和单独使用任何一种药物更有效。
A randomised placebo controlled study was performed in 32 women with intrahepatic cholestasis of pregnancy. The population was divided into four groups: for 20 days each group was treated only with ursodeoxycholic acid, or S-adenosylmethionine, or a combination of both drugs, or a placebo (vitamin). Itching, standard liver function tests and serum total bile acids were measured before, during, and after treatment. Itching improved in all the women as well as the biochemical abnormalities. No side-effects in the mother or in the infant were recorded during and after therapy. A combination of ursodeoxycholic acid and S-adenosylmethionine is more effective than placebo and than either drug alone.