Polymyxin B-immobilized Fiber Column (PMX) Treatment for Idiopathic Pulmonary Fibrosis with Acute Exacerbation: A Multicenter Retrospective Analysis
Polymyxin B-immobilized Fiber Column (PMX) Treatment for Idiopathic Pulmonary Fibrosis with Acute Exacerbation: A Multicenter Retrospective Analysis
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DOI：
10.2169/internalmedicine.51.6965
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发表时间：
2012-01-01
影响因子：
1.2
通讯作者：
Sugiyama, Yukihiko
中科院分区：
文献类型：
--
作者：
Abe, Shinji;Azuma, Arata;Sugiyama, Yukihiko
目的特发性肺纤维化（IPF）急性加重期（AE）患者预后极差。多项临床研究表明，多粘菌素B固定纤维（PMX）直接血液灌流可能对间质性肺炎（IP）患者的AE具有有益作用。这个多中心的回顾性分析的目的是调查PMX治疗是否可以提供改善肺间质纤维化患者的氧合和生存的好处AE.Methods我们进行了一项回顾性研究，160 IP患者（包括73 IPF）在18个机构在日本PMX治疗的AE。PMX处理进行两次。PMX治疗的总血液灌流时间平均为12小时。结果在伴有AE的IPF患者中，动脉血氧分压（PaO 2）/吸入氧分数（FiO（2））（P/F）比值在第2次PMX治疗结束时显著改善（173.9 ± 105.4至195.2 ± 106.8 Torr，p=0.003）。在第二次治疗结束时，白色血细胞计数显著降低（13，330 +/-7，002至9，426 +/-5，188/mm（3），p
Objective The prognosis of idiopathic pulmonary fibrosis (IPF) patients with acute exacerbation (AE) is reported to be extremely poor. Several clinical studies suggest that direct hemoperfusion with polymyxin Bimmobilized fiber (PMX) may have beneficial effects on AE in patients with interstitial pneumonia (IP). The aim of this multicenter retrospective analysis was to investigate whether PMX treatment could provide improvement of oxygenation and survival benefits in IPF patients with AE.Methods We conducted a retrospective study of 160 IP patients (including 73 IPF) with AE treated by PMX at 18 institutions in Japan. PMX treatment was carried out twice. The total hemoperfusion time of PMX treatment was, on average, 12 hours. Data concerning oxygenation on PMX treatment and survival after AE were collected and analyzed.Results In IPF patients with AE, arterial oxygen tension (PaO2)/inspiratory oxygen fraction (FiO(2)), (P/F) ratio was significantly improved at the end of the 2nd treatment with PMX (173.9 +/- 105.4 to 195.2 +/- 106.8 Torr, p=0.003). White blood cell count was significantly reduced at the end of the 2nd treatment (13,330 +/- 7,002 to 9,426 +/- 5,188/mm(3), p