Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering.
Multifaceted signaling regulators of chondrogenesis: Implications in cartilage regeneration and tissue engineering.
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软骨发生的多方面信号调节剂：软骨再生和组织工程的影响。
DOI：
10.1016/j.gendis.2015.09.003
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发表时间：
2015-12
期刊：
影响因子：
6.8
通讯作者：
Athiviraham A
中科院分区：
文献类型：
--
作者：
Green JD;Tollemar V;Dougherty M;Yan Z;Yin L;Ye J;Collier Z;Mohammed MK;Haydon RC;Luu HH;Kang R;Lee MJ;Ho SH;He TC;Shi LL;Athiviraham A
关节软骨缺损由于其自身愈合能力差和无血管性，给临床带来了独特的挑战。目前的手术治疗选择不能确保透明软骨的再生有利于纤维组织。在这里，我们回顾了目前的理解最重要的生物调节剂的软骨形成和它们之间的相互作用，提供深入了解软骨组织工程的潜在应用。这些包括各种信号传导途径，包括成纤维细胞生长因子（FGF）、转化生长因子β（TGF-β）/骨形态发生蛋白（BMP）、Wnt/β-连环蛋白、Hedgehog、Notch、缺氧和血管生成信号传导途径。软骨形成的转录和表观遗传调控也将讨论。我们对这些信号通路的理解的进展已经导致了软骨再生和组织工程的有希望的进展。
Defects of articular cartilage present a unique clinical challenge due to its poor self-healing capacity and avascular nature. Current surgical treatment options do not ensure consistent regeneration of hyaline cartilage in favor of fibrous tissue. Here, we review the current understanding of the most important biological regulators of chondrogenesis and their interactions, to provide insight into potential applications for cartilage tissue engineering. These include various signaling pathways, including fibroblast growth factors (FGFs), transforming growth factor β (TGF-β)/bone morphogenic proteins (BMPs), Wnt/β-catenin, Hedgehog, Notch, hypoxia, and angiogenic signaling pathways. Transcriptional and epigenetic regulation of chondrogenesis will also be discussed. Advances in our understanding of these signaling pathways have led to promising advances in cartilage regeneration and tissue engineering.