Chronic inflammatory demyelinating polyradiculoneuropathy with histologically proven optic neuritis
Chronic inflammatory demyelinating polyradiculoneuropathy with histologically proven optic neuritis
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慢性炎症性脱髓鞘性多发性神经根神经病伴组织学证实的视神经炎
DOI：
10.1007/s004010000309
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发表时间：
2001
影响因子：
12.7
通讯作者：
J. Weber
中科院分区：
文献类型：
--
作者：
M. Holtkamp;R. Zschenderlein;W. Brück;J. Weber
虽然慢性炎性脱髓鞘性多发性神经根神经病（CIDP）患者中枢神经系统受累的临床、电生理或磁共振成像证据已发表，但组织学证据从未报道。我们提出的情况下，46岁的男性患者谁开发CIDP在他20岁出头，谁死于复发性严重肺炎。在疾病的晚期，患者出现视力丧失和双侧视神经萎缩。神经病理学检查显示严重的周围神经病变符合CIDP和中央受累与双侧视神经炎。这是第一例报告CIDP和组织学证实的视神经炎。
Although patient series of clinical, electrophysiological, or magnetic resonance imaging evidence for involvement of the central nervous system in patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) have been published, the histological proof has never been reported. We present the case of a 46-year-old male patient who developed CIDP in his early 20s and who died of relapsing severe pneumonia. In late stages of the disease the patient presented visual loss and bilateral atrophy of the optic nerve. Neuropathological examination revealed severe peripheral neuropathy consistent with CIDP and central involvement with bilateral optic neuritis. This is the first case reporting CIDP and histologically proven optic neuritis.