Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats
Chronobiological disturbances with hyperthermia and hypercortisolism induced by chronic mild stress in rats
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DOI：
10.1016/j.bbr.2006.06.038
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发表时间：
2006-10
影响因子：
2.7
通讯作者：
K. Ushijima;T. Morikawa;H. To;S. Higuchi;S. Ohdo
中科院分区：
文献类型：
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作者：
K. Ushijima;T. Morikawa;H. To;S. Higuchi;S. Ohdo
慢性轻度应激(CMS)模型模拟快感缺乏，已被建立为抑郁症的现实模型。在本研究中，接触CMS的大鼠对蔗糖溶液的消耗减少，这与许多已发表的研究相一致。由于抑郁症是一种多方面的疾病，并且可能存在许多症状，包括昼夜节律紊乱，我们试图发现CMS大鼠的时间生物学异常。应激4周后，CMS组大鼠直肠温度节律性消失。特别是，CMS组的光相温度显著高于对照组。CMS组大鼠血浆皮质酮水平在光期较对照组显著升高，但在暗期无明显变化。结论：CMS手术引起了体温过高和皮质醇过高的昼夜节律紊乱。
The chronic mild stress (CMS) model has been established as a realistic model of depressive disorder as it simulates anhedonia. In the present study, the consumption of sucrose solution was decreased in the rats exposed to CMS, which coincided with many published studies. Since depression is a multifaceted disorder, and a number of symptoms may be present, including circadian rhythm disturbances, we attempted to find the chronobiological abnormalities in CMS rats. After 4-week of the stress procedure, the rhythmic pattern of rectal temperature in the CMS group was extinguished. In particular, the temperature in the CMS group in the light phase was significantly higher than that in the control group. The plasma corticosterone levels in the CMS group were remarkably increased in the light phase compared to the control group, but not in the dark phase. It was concluded that the CMS procedure caused the disturbance of circadian rhythms with hyperthermia and hypercortisolism.