Toll-like receptors and their role in persistent pain.
Toll-like receptors and their role in persistent pain.
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DOI：
10.1016/j.pharmthera.2017.10.006
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发表时间：
2018-04
影响因子：
13.5
通讯作者：
Grace PM
中科院分区：
文献类型：
--
作者：
Lacagnina MJ;Watkins LR;Grace PM
先天免疫系统协调炎症信号转导的基本机制之一是通过 Toll 样受体 (TLR)，其通过响应组织损伤或损伤而启动炎症信号级联反应来保护和防御宿主生物体。 TLR 位于神经免疫界面，越来越多的证据表明，TLR 激活对神经胶质细胞（包括小胶质细胞和星形胶质细胞）、感觉神经元和其他细胞类型的炎症后果可以影响伤害感受处理，并导致夸大和无法解决的疼痛状态。在这篇综述中，我们总结了目前对不同 TLR 及其辅助分子如何促进持续性疼痛的发展和维持的理解。讨论了针对 TLR 的新治疗策略针对慢性疼痛的挑战和机遇，包括阿片类镇痛和化疗引起的疼痛中 TLR 介导的信号传导的治疗背景。考虑到持续性疼痛的普遍存在以及当前治疗方案的有效性和安全性不足，对 Toll 样受体的更深入了解有望为治疗病理性疼痛提供新的疗法。
One of the fundamental mechanisms whereby the innate immune system coordinates inflammatory signal transduction is through Toll-like receptors (TLRs), which function to protect and defend the host organism by initiating inflammatory signaling cascades in response to tissue damage or injury. TLRs are positioned at the neuroimmune interface, and accumulating evidence suggests that the inflammatory consequences of TLR activation on glia (including microglia and astrocytes), sensory neurons, and other cell types can influence nociceptive processing and lead to states of exaggerated and unresolved pain. In this review, we summarize our current understanding of how different TLRs and their accessory molecules can contribute to the development and maintenance of persistent pain. The challenges and opportunities of targeting TLRs for new treatment strategies against chronic pain are discussed, including the therapeutic context of TLR-mediated signaling in opioid analgesia and chemotherapy-induced pain. Considering the prevalence of persistent pain and the insufficient efficacy and safety of current treatment options, a deeper understanding of Toll-like receptors holds the promise of novel therapies for managing pathological pain.
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DOI：
10.1016/j.bbi.2014.06.199
发表时间：
2014-11
期刊：
Brain, behavior, and immunity
影响因子：
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作者：
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影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.1073/pnas.0505077102
发表时间：
2005-08-02
影响因子：
11.1
作者：
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通讯作者：
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