Multidrug-resistant Mycobacterium tuberculosis in HIV-infected persons, Peru.
Multidrug-resistant Mycobacterium tuberculosis in HIV-infected persons, Peru.
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DOI：
10.3201/eid0912.020731
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发表时间：
2003-12
影响因子：
11.8
通讯作者：
Holmes KK
中科院分区：
文献类型：
--
作者：
Campos PE;Suarez PG;Sanchez J;Zavala D;Arevalo J;Ticona E;Nolan CM;Hooton TM;Holmes KK
在1999年至2000年期间，我们在利马-秘鲁的10家医院中发现了艾滋病毒感染者新发结核病（TB），并随机抽样了利马其他患有结核病的居民。81例HIV阳性患者中有35例（43%）记录为多药耐药（MDR）结核，965例HIV阴性或HIV状态未知的患者中有38例（3.9%）记录为多药耐药结核（p < 0.001）。耐多药结核病艾滋病毒阳性患者集中在治疗艾滋病毒感染结核病患者最多的三家医院。在结核病患者中，感染艾滋病毒的患者与未感染艾滋病毒的患者的不同之处在于，他们以前更频繁地接触过临床服务，并且以前接受过更频繁的结核病治疗或预防。然而，hiv感染患者的耐多药结核病与以前的结核病治疗或预防无关。在利马和卡亚俄的公立医院接受治疗的艾滋病毒感染者中，耐多药结核病是一个持续存在的问题；它们是院内耐多药结核病可能更大流行的前哨病例。
During 1999 to 2000, we identified HIV-infected persons with new episodes of tuberculosis (TB) at 10 hospitals in Lima-Peru and a random sample of other Lima residents with TB. Multidrug-resistant (MDR)-TB was documented in 35 (43%) of 81 HIV-positive patients and 38 (3.9%)of 965 patients who were HIV-negative or of unknown HIV status (p < 0.001). HIV-positive patients with MDR-TB were concentrated at three hospitals that treat the greatest numbers of HIV-infected persons with TB. Of patients with TB, those with HIV infection differed from those without known HIV infection in having more frequent prior exposure to clinical services and more frequent previous TB therapy or prophylaxis. However, MDR-TB in HIV-infected patients was not associated with previous TB therapy or prophylaxis. MDR-TB is an ongoing problem in HIV-infected persons receiving care in public hospitals in Lima and Callao; they represent sentinel cases for a potentially larger epidemic of nosocomial MDR-TB.