EFFECT OF LATENCY ON CALCULATED COMPLICATION RATES
EFFECT OF LATENCY ON CALCULATED COMPLICATION RATES
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DOI：
10.1016/0360-3016(86)90331-7
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发表时间：
1986-10-01
影响因子：
7
通讯作者：
DIXON, DO
中科院分区：
文献类型：
--
作者：
SCHULTHEISS, TE;THAMES, HD;DIXON, DO
由于癌症患者的生存期缩短，放射治疗和其他癌症治疗的晚期并发症可能并不总是表现出来。估计真实并发症发生率的方法必须考虑数据审查。精算方法给出了不受伤害的与时间相关的概率。然而，当最后一位幸存的患者出现并发症时，这些方法就会失败。本研究描述了计算校正并发症发生率的不同方法。该方法的一个优点是，当最后一位幸存者遭受并发症时，使用精算方法不会对发生的并发症发生率进行 100% 的估计。要使用此处介绍的方法，必须确定损伤潜伏期的分布和处于危险中的患者的生存函数。
Late complication of radiation therapy and other cancer therapies may not always be expressed because of the shortened survival of cancer patients. Methods for estimating the true complication rate must account for censoring of the data. Actuarial methods give the time-dependent probability of remaining free of the injury. However, these methods fail when the last surviving patient develops a complication. This study describes a different method for calculating the corrected complication rate. One advantage is that the method does not produce estimates of 100% for the complication rate that occur using the actuarial method when the last survivor suffers a complication. To use the method presented here, the distribution of latent periods of the injury and the survival function for the patients at risk must be identified.