Lymphoscintigraphic findings in patients with lipedema
Lymphoscintigraphic findings in patients with lipedema
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DOI：
10.1016/j.remn.2018.06.008
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发表时间：
2018-11-01
影响因子：
1.2
通讯作者：
Munoz-Langa, J.
中科院分区：
文献类型：
--
作者：
Forner-Cordero, I.;Olivan-Sasot, P.;Munoz-Langa, J.
简介：脂肪水肿是一种以水肿、下肢脂肪堆积、疼痛和血肿为特征的综合征，主要影响女性。目前的诊断是基于临床标准，因为没有准确的诊断成像。本研究的目的是描述脂水肿患者的淋巴显像表现。材料和方法：一项前瞻性队列研究，对有临床标准的脂水肿妇女进行淋巴显像检查。根据放射性药物的迁移和分布，两名独立的核医生描述并分类了不同严重程度的淋巴显像结果。83例患者纳入研究，中位年龄49.7岁（范围：18-80），平均体重指数（BMI）为29.9 kg/m(2) （95% CI: 28.4-31.3）。结果：47%的患者淋巴显像显示改变，大多数为低（35.9%）或中低级别（48.7%）。所有患者均未受到严重影响（无放射性药物迁移）。淋巴显像受累程度与年龄（P= .674）、Stemmer氏征（P= .506）或BMI （P= .832）无关。我们发现淋巴显像在脂水肿的所有临床分期中都有发现，淋巴显像受累的程度和脂水肿的临床分期之间没有显著差异（P= .142）。结论：虽然淋巴显像已被用于区分脂性水肿和淋巴水肿，但我们发现脂性水肿患者经常发生改变，因此这些发现不能排除唇部水肿的诊断。(C) 2018西班牙核与影像医学学会。Elsevier Espana， S.L.U.出版，版权所有。
Introduction: Lipedema is a syndrome that is characterised by edema, an accumulation of fat, pain and haematomas in the lower limbs that principally affects women. Diagnosis is currently based on clinical criteria, since there is no accurate diagnostic imaging for the condition. The aim of our study was to describe the lymphoscintigraphic findings in patients with lipedema.Material and method: A prospective cohort study of women with clinical criteria of lipedema who underwent lymphoscintigraphy. Two independent nuclear physicians described and classified the lymphoscintigraphy findings in different grades of severity, according to the migration and distribution of the radiopharmaceutical.Eighty three patients were included with a median age of 49.7 years (range: 18-80) and a mean body mass index (BMI) of 29.9 kg/m(2) (95% CI: 28.4-31.3)Results: Lymphoscintigraphy showed alterations in 47% of the patients, most were low (35.9%) or low-moderate grade (48.7%). None of the patients were severely affected (no migration of the radiopharmaceutical).The degree of lymphoscintigraphic involvement bore no relation to age (P= .674), Stemmer's sign (P= .506), or BMI (P= .832). We found lymphoscintigraphy findings in all the clinical stages of lipedema, with no significant differences between the grade of lymphoscintigraphic involvement and the clinical stage of lipedema (P= .142).Conclusion: Although lymphoscintigraphy has been used to differentiate lipedema from lymphedema, we found frequent alterations in the patients with lipedema, therefore the presence of findings dues not discount a diagnosis of lip 1 aedema. (C) 2018 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved.