Coordination of actions and habits in the medial prefrontal cortex of rats
Coordination of actions and habits in the medial prefrontal cortex of rats
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DOI：
10.1093/cercor/13.4.400
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发表时间：
2003-04-01
期刊：
影响因子：
3.7
通讯作者：
Coutureau, E
中科院分区：
文献类型：
--
作者：
Killcross, S;Coutureau, E
随着动物学习新的行为反应，表现由两个分离的影响维持。最初的反应是以目标为导向的，并受自愿控制，但过度训练相同的反应程序会导致行为自主性，并导致不再是自愿或目标导向的习惯的养成。老鼠通常在有限的训练后表现出目标导向的表现，通过对奖励价值变化的敏感度来衡量，但随着训练的延长，这种对目标价值的敏感度就会消失。选择性损毁前内侧前额叶皮质的大鼠在有限或延长训练后对目标值不敏感，而损毁内侧前额叶下缘区的大鼠则表现出相反的缺失模式，在有限和延长训练后对目标值都有显著的敏感性。这种双重分离表明，前脑区域负责自愿反应表现，而下缘皮质调节延长训练的递增能力，以超越这种目标导向的行为。
As animals learn novel behavioural responses, performance is maintained by two dissociable influences. Initial responding is goal-directed and under voluntary control, but overtraining of the same response routine leads to behavioural autonomy and the development of habits that are no longer voluntary or goal-directed. Rats normally show goal-directed performance after limited training, indexed by sensitivity to changes in the value of reward, but this sensitivity to goal value is lost with extended training. Rats with selective lesions of the prelimbic medial prefrontal cortex showed no sensitivity to goal value after either limited or extended training, whereas rats with lesions of the infralimbic region of the medial prefrontal cortex showed the opposite pattern of deficit, a marked sensitivity to goal value after both limited and extended training. This double-dissociation suggests that the prelimbic region is responsible for voluntary response performance and the infralimbic cortex mediates the incremental ability of extended training to override this goal-directed behaviour.