Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects.
Demonstration of granulocytic proteases in plasma of patients with acute leukemia and septicemia with coagulation defects.
复制标题
患有凝血缺陷的急性白血病和败血症患者血浆中粒细胞蛋白酶的证明。
DOI：
10.1182/blood.v49.2.219.219
复制
发表时间：
1977
期刊：
影响因子：
20.3
通讯作者：
K. Havemann
中科院分区：
文献类型：
--
作者：
R. Egbring;W. Schmidt;G. Fuchs;K. Havemann
To show whether direct proteolysis of coagulation factors may play a role in patients with so-called consumption coagulopathy, granulocytic neutral proteases in the plasma of patients with acute myelocytic leukemia and septicemia were assayed by one- and two-dimensional Laurell electrophoresis. Complexes between serum alpha1-antitrypsin and elastase-like granulocytic protease could be demonstrated in those patients with acute myelocytic leukemia and septicemia who also had moderate or severe coagulation defects. Despite the presence of a high antiprotease potential, addition of the elastase-like enzyme to normal plasma resulted in coagulation defects in vitro comparable to those seen in the patients. These results and the ability of the elastase-like protease to destroy isolated clotting factors suggested that in certain types of coagulation factor deficiencies direct proteolysis rather than consumption of clotting factors due to disseminated intravascular coagulation may be operational.
