Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.
Immunization with nonstructural proteins E1 and E2 of cottontail rabbit papillomavirus stimulates regression of virus-induced papillomas.
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用棉尾兔乳头瘤病毒的非结构蛋白 E1 和 E2 进行免疫可刺激病毒诱导的乳头状瘤消退。
DOI：
10.1128/jvi.69.1.602-605.1995
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Wettstein,FO
中科院分区：
文献类型：
--
作者：
Selvakumar,R;Borenstein,LA;Lin,YL;Ahmed,R;Wettstein,FO
棉尾兔乳头瘤病毒是肿瘤相关乳头瘤病毒的主要动物模型。本研究表明，接种非结构蛋白E1和E2可诱导病毒诱导的乳头状瘤的消退，并且无论是否接种佐剂，接种疫苗的效果都是一样的。抗体水平与肿瘤消退之间没有相关性，提示肿瘤消退可能是由于细胞介导的反应。
Cottontail rabbit papillomavirus is the major animal model for cancer-associated papillomaviruses. Here we show that vaccination with the nonstructural proteins E1 and E2 induces the regression of virus-induced papillomas and that vaccination is equally effective when proteins are given with and without adjuvant. There was no correlation between antibody levels and regression, suggesting that tumor regression may be due to a cell-mediated response.