Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors.
Changes in blood lymphocyte numbers with age in vivo and their association with the levels of cytokines/cytokine receptors.
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DOI：
10.1186/s12979-016-0079-7
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Weng NP
中科院分区：
文献类型：
--
作者：
Lin Y;Kim J;Metter EJ;Nguyen H;Truong T;Lustig A;Ferrucci L;Weng NP
血液中淋巴细胞及其亚群的数量和组成的改变被认为是免疫系统衰老的标志。然而，尚不清楚淋巴细胞的变化率是否稳定或随年龄而变化，或者淋巴细胞组成的个体间变异是否随时间稳定或在不同年龄时经历不同的变化率。在这里，我们报告了对 165 名年龄从 24 岁到 90 岁的受试者血液中的 T 细胞和 B 细胞及其亚群以及 NK 细胞的纵向分析，每个受试者都在基线和平均 5.6 年的随访中进行了评估。 T 细胞（CD4+ 和 CD8+）和 B 细胞以及 NK 细胞的变化率在整个成年过程中相对稳定。观察到淋巴细胞及其亚群的数量及其随年龄变化的速率存在很大程度的个体差异。其中，CD4+T细胞个体变异程度最高，其次是NK细胞、CD8+T细胞和B细胞。不同类型的淋巴细胞的变化率有不同的趋势，但似乎不受巨细胞病毒感染的影响。最后，CD4+、CD8+ T 细胞、初始 CD4+ 和初始 CD8+ T 细胞的比率密切正相关。我们的研究结果提供了证据，表明循环淋巴细胞中与年龄相关的变化在体内以高度个体化的方式处于相对稳定的速率，并且血清中选定的细胞因子/细胞因子受体的水平可能影响循环中淋巴细胞的这些与年龄相关的变化。本文的在线版本 (doi:10.1186/s12979-016-0079-7) 包含补充材料，可供授权用户使用。
Alterations in the number and composition of lymphocytes and their subsets in blood are considered a hallmark of immune system aging. However, it is unknown whether the rates of change of lymphocytes are stable or change with age, or whether the inter-individual variations of lymphocyte composition are stable over time or undergo different rates of change at different ages. Here, we report a longitudinal analysis of T- and B-cells and their subsets, and NK cells in the blood of 165 subjects aged from 24 to 90 years, with each subject assessed at baseline and an average of 5.6 years follow-up. The rates of change of T-(CD4+ and CD8+) and B-cells, and NK cells were relative stable throughout the adult life. A great degree of individual variations in numbers of lymphocytes and their subsets and in the rates of their changes with age was observed. Among them, CD4+ T cells exhibited the highest degree of individual variation followed by NK cells, CD8+ T cells, and B cells. Different types of lymphocytes had distinct trends in their rates of change which did not appear to be influenced by CMV infection. Finally, the rates of CD4+, CD8+ T cells, naive CD4+ and naïve CD8+ T cells were closely positively correlated. Our findings provide evidence that the age-associated changes in circulating lymphocytes were at relative stable rates in vivo in a highly individualized manner and the levels of selected cytokines/cytokine receptors in serum might influence these age-associated changes of lymphocytes in circulation. The online version of this article (doi:10.1186/s12979-016-0079-7) contains supplementary material, which is available to authorized users.