Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum
Plin3 protects against alcoholic liver injury by facilitating lipid export from the endoplasmic reticulum
复制标题
Plin3 通过促进内质网脂质输出来防止酒精性肝损伤
DOI：
10.1002/jcb.28889
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发表时间：
2019-09-01
影响因子：
4
通讯作者：
Ye, Jing
中科院分区：
文献类型：
--
作者：
Gu, Yu;Yang, Ying;Ye, Jing
肝脏脂质蓄积是酒精性肝病最常见的病理特征。在哺乳动物细胞中，过量的中性脂质储存在脂滴（LD）中。Plin3作为perilipin家族的一员，最近被发现参与调节LD的发生。然而，Plin3在ALD进展中的作用和机制仍不清楚。
Hepatic lipid accumulation is the most common pathological characteristic of alcoholic liver disease (ALD). In mammalian cells, excess neutral lipids are stored in lipid droplets (LDs). As a member of perilipin family proteins, Plin3 was recently found to regulate the LD biogenesis. However, the roles and mechanism of Plin3 in ALD progression remain unclear.