Breath timing, volume and drive to breathe in conscious rats: Comparative aspects
Breath timing, volume and drive to breathe in conscious rats: Comparative aspects
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DOI：
10.1016/s0034-5687(96)02520-0
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发表时间：
1997-03-01
期刊：
影响因子：
--
通讯作者：
Jennings, DB
中科院分区：
文献类型：
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作者：
Walker, JKL;Lawson, BL;Jennings, DB
在清醒的动物中，呼吸频率(F)和潮气量(VT)随呼吸而变化。检查与另一个变量的特定区间相关的变量的平均值，例如呼吸f，为检查呼吸行为提供了一个独特的工具。用体积描记仪测定清醒SD大鼠的呼吸计时、潮气量(VT)和驱动力(VT/Tr)。在大多数大鼠中，在低呼吸f时，呼气时间(TE)超过吸气时间(TI)，当f超过150次/分钟时，这些时间变得相等；没有证据表明，在较高f时，TI大于TE，就像在猫和狗中观察到的那样。当VT每公斤归一化时，大鼠的呼吸VT和VT/TI在最低呼吸f处与猫和非喘息犬的VT和VT/TI连续。相对于呼吸f，大鼠的呼吸VT和VT/TI大于常温喘息犬(20摄氏度)，但仅略大于高温(30摄氏度)喘息犬的这些变量。猫和狗的呼吸VT/TI值较低，由呼吸f或(V)Over Dot来补偿，相对于给定呼吸的持续时间，TI较大。这种比较分析表明，不同物种之间呼吸模式的产生是连续的。(C)1997年爱思唯尔科学公司。
In conscious animals, respiratory frequency (f) and tidal volume (VT) vary breath to breath. Examining the average value of variables associated with specific bins of another variable, such as breath f, provides a unique tool to examine respiratory behaviour. In conscious Sprague-Dawley rats respiratory breath timing, tidal volume (VT) and drive (VT/Tr) were characterized using a plethysmograph. In the majority of rats at low breath f, expiratory time (TE) exceeded inspiratory time (TI) and these times became equal as f exceeded 150 breaths/min; there was no evidence for TI greater than TE at higher f, as observed in cats and dogs. When VT is normalized per kg, rat breath VT and VT/TI, binned by breath f, are continuous with those for the cat and non-panting dog at the lowest breath f. Relative to breath f, breath VT and VT/TI in rats are greater than in normothermic panting dogs (20 degrees C), but only slightly greater than those variables in panting dogs in the heat (30 degrees C). Lower values of breath VT/TI, binned by breath f or (V) over dot, in cats and dogs are compensated for by a greater TI relative to the duration of a given breath. This comparative analysis suggests continuities of respiratory pattern generation among species. (C) 1997 Elsevier Science B.V.