Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.
Polysaccharides from Ganoderma lucidum Promote Cognitive Function and Neural Progenitor Proliferation in Mouse Model of Alzheimer's Disease.
复制标题
DOI：
10.1016/j.stemcr.2016.12.007
复制
发表时间：
2017-01-10
影响因子：
5.9
通讯作者：
Pei G
中科院分区：
文献类型：
--
作者：
Huang S;Mao J;Ding K;Zhou Y;Zeng X;Yang W;Wang P;Zhao C;Yao J;Xia P;Pei G
促进神经发生是治疗阿尔茨海默病(AD)相关认知障碍的一种有前景的策略。灵芝是东方著名的保健药用蘑菇。在这里，我们发现口服灵芝多糖和水提取物可以促进神经前体细胞(NPC)的增殖，以促进神经发生，并缓解转基因AD小鼠的认知障碍。灵芝多糖(GLP)也能促进鼻咽癌细胞培养的自我更新。进一步的机制研究表明，GLP增强成纤维细胞生长因子受体1(FGFR1)及其下游的细胞外信号调节激酶(ERK)和AKT的激活。一致地，抑制FGFR1有效地阻断了GLP促进的NPC增殖和下游级联的激活。我们的发现表明，GLP可以作为一种再生治疗剂来治疗与神经退行性疾病相关的认知衰退。灵芝多糖(GLP)可改善转基因AD小鼠的认知功能，促进神经前体细胞的增殖和自我更新，促进神经发生，增强FGFR信号转导，是一种备受推崇的保健药材。贝和他的同事发现，灵芝多糖(GLP)促进神经前体细胞的增殖，以促进神经发生，并改善转基因阿尔茨海默病模型小鼠的认知缺陷。这些发现表明，GLP可以作为一种再生治疗剂来治疗与神经退行性疾病相关的认知衰退。
Promoting neurogenesis is a promising strategy for the treatment of cognition impairment associated with Alzheimer's disease (AD). Ganoderma lucidum is a revered medicinal mushroom for health-promoting benefits in the Orient. Here, we found that oral administration of the polysaccharides and water extract from G. lucidum promoted neural progenitor cell (NPC) proliferation to enhance neurogenesis and alleviated cognitive deficits in transgenic AD mice. G. lucidum polysaccharides (GLP) also promoted self-renewal of NPC in cell culture. Further mechanistic study revealed that GLP potentiated activation of fibroblast growth factor receptor 1 (FGFR1) and downstream extracellular signal-regulated kinase (ERK) and AKT cascades. Consistently, inhibition of FGFR1 effectively blocked the GLP-promoted NPC proliferation and activation of the downstream cascades. Our findings suggest that GLP could serve as a regenerative therapeutic agent for the treatment of cognitive decline associated with neurodegenerative diseases. G. lucidum polysaccharides (GLP) improve cognition in transgenic AD mice GLP promote neural progenitor proliferation and self-renewal to enhance neurogenesis GLP potentiate FGFR signaling G. lucidum is a revered medicinal herb for promoting health. Pei and colleagues found that the polysaccharides from G. lucidum (GLP) promoted neural progenitor proliferation to enhance neurogenesis and ameliorated cognition deficits in transgenic Alzheimer's disease model mice. These findings suggest that GLP could serve as a regenerative therapeutic agent for the treatment of cognitive decline associated with neurodegenerative diseases.