OMIP 078: A 31‐parameter panel for comprehensive immunophenotyping of multiple immune cells in human peripheral blood mononuclear cells
OMIP 078: A 31‐parameter panel for comprehensive immunophenotyping of multiple immune cells in human peripheral blood mononuclear cells
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DOI：
10.1002/cyto.a.24490
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发表时间：
2021-08
期刊：
影响因子：
3.7
通讯作者：
T. Nogimori;Yuko Sugawara;Masaya Higashiguchi;Hirotomo Murakami;H. Akita;Shokichi Takahama;Satoshi Tanaka;Takuya Yamamoto
中科院分区：
文献类型：
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作者：
T. Nogimori;Yuko Sugawara;Masaya Higashiguchi;Hirotomo Murakami;H. Akita;Shokichi Takahama;Satoshi Tanaka;Takuya Yamamoto
这个31个参数的面板是为了同时检测人类外周血单核细胞中的多种免疫细胞群体而开发的，包括T细胞、B细胞、自然杀伤细胞、树突状细胞、单核细胞和造血祖细胞。该面板能够捕获个体免疫动态，并评估与衰老和疾病相关的免疫系统中的单细胞变化。该小组包括用于区分每个细胞群体的分化状态的标记，可能适用于传染病和自身免疫性疾病的研究，因为患者样本的数量通常有限，需要一个提供相对大量信息的分析系统。
This 31‐parameter panel was developed for simultaneously measuring multiple immune cell populations including T cells, B cells, natural killer cells, dendritic cells, monocytes, and hematopoietic progenitor cells in human peripheral blood mononuclear cells. This panel enables the capture of individual immune dynamics and assessments of single‐cell changes in the immune system that are associated with aging and diseases. This panel includes markers to separate the differentiation status of each cell population and might be applicable to studies of infectious and autoimmune diseases, as patient samples are usually limited in volume and require an analysis system that provides a relatively large amount of information.