Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry
Cytotoxicity-Related Bioeffects Induced by Nanoparticles: The Role of Surface Chemistry
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DOI：
10.3389/fbioe.2019.00414
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发表时间：
2019-12
影响因子：
5.7
通讯作者：
Hainan Sun;Cuijuan Jiang;Ling-hua Wu;Xue Bai;Shumei Zhai
中科院分区：
文献类型：
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作者：
Hainan Sun;Cuijuan Jiang;Ling-hua Wu;Xue Bai;Shumei Zhai
纳米颗粒（NPs）广泛应用于各种领域，包括与消费品、建筑、能源和生物医学相关的领域。一旦它们进入人体，NPs接触血液中的蛋白质并与器官中的细胞相互作用，这可能会诱导细胞毒性。在NP表面化学的各种因素中，表面电荷、疏水性水平和组合修饰被发现在调节典型的细胞毒性相关的生物效应中起关键作用，包括蛋白质结合、细胞摄取、氧化应激、自噬、炎症和凋亡。在这篇综述中，我们总结了最近取得的进展，在指导这些细胞毒性相关的影响的水平和分子途径的有目的的设计NP表面电荷，疏水性和组合装饰。
Nanoparticles (NPs) are widely used in a variety of fields, including those related to consumer products, architecture, energy, and biomedicine. Once they enter the human body, NPs contact proteins in the blood and interact with cells in organs, which may induce cytotoxicity. Among the various factors of NP surface chemistry, surface charges, hydrophobicity levels and combinatorial decorations are found to play key roles inregulating typical cytotoxicity-related bioeffects, including protein binding, cellular uptake, oxidative stress, autophagy, inflammation, and apoptosis. In this review, we summarize the recent progress made in directing the levels and molecular pathways of these cytotoxicity-related effects by the purposeful design of NP surface charge, hydrophobicity, and combinatorial decorations.