INVOLVEMENT OF THE CENTRAL NUCLEUS AND BASOLATERAL COMPLEX OF THE AMYGDALA IN FEAR CONDITIONING MEASURED WITH FEAR-POTENTIATED STARTLE IN RATS TRAINED CONCURRENTLY WITH AUDITORY AND VISUAL CONDITIONED-STIMULI
INVOLVEMENT OF THE CENTRAL NUCLEUS AND BASOLATERAL COMPLEX OF THE AMYGDALA IN FEAR CONDITIONING MEASURED WITH FEAR-POTENTIATED STARTLE IN RATS TRAINED CONCURRENTLY WITH AUDITORY AND VISUAL CONDITIONED-STIMULI
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DOI：
10.1523/jneurosci.15-03-02301.1995
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发表时间：
1995-03-01
影响因子：
5.3
通讯作者：
DAVIS, M
中科院分区：
文献类型：
--
作者：
CAMPEAU, S;DAVIS, M
这项工作的目的是测试参与中央核和基底外侧复合体的杏仁核恐惧条件反射，使用听觉和视觉条件刺激（CS）。大鼠的声惊吓反射被用作条件反射的行为指标，因为惊吓在先前与足电击配对的条件刺激（CS）存在下可靠地增强。最初，差分条件反射程序表明噪声CS和视觉CS之间的可靠区分。随后，杏仁核病变的影响进行了评估时，这两种方式与休克配对在同一大鼠。杏仁核中央核的电解质或鹅膏蕈氨酸损伤阻断了听觉和视觉CS的恐惧增强惊吓，这与中央核作为反应独立的、恐惧条件反射的最终共同中继的想法一致。同样，训练前或训练后电解质或NMDA诱导的杏仁核基底外侧复合体损伤，损害了外侧核和大部分基底外侧核，破坏了CS模式的恐惧增强惊吓。这一发现是一致的建议，在恐惧条件反射，杏仁核的基底外侧复合体作为一个强制性的中继的感觉信息从皮层下和皮层感觉区的中央核杏仁核。
The goal of this work was to test the involvement of the central nucleus and basolateral complex of the amygdala in fear conditioning, using auditory and visual conditioned stimuli (CSs). The acoustic startle reflex in rats was used as the behavioral index of conditioning because startle is reliably enhanced in the presence of a conditioned stimulus (CS) previously paired with a footshock. Initially, differential conditioning procedures indicated reliable discrimination between a noise CS and a visual CS. Subsequently, the effects of amygdala lesions were evaluated when both modalities were paired with shocks in the same rats. Electrolytic or ibotenic acid lesions of the central nucleus of the amygdala blocked fear-potentiated startle to both auditory and visual CSs, consistent with the idea that the central nucleus serves as a response independent, final common relay for fear conditioning. Similarly, pre- or posttraining electrolytic or NMDA-induced lesions of the basolateral complex of the amygdala, which damaged the lateral nucleus, and most of the basolateral nucleus, disrupted fear-potentiated startle to both CS modalities. This finding is consistent with the suggestion that, in fear conditioning, the basolateral complex of the amygdala serves as an obligatory relay of sensory information from subcortical and cortical sensory areas to the central nucleus of the amygdala.