A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures
A critical review on the participation of inferior colliculus in acoustic-motor and acoustic-limbic networks involved in the expression of acute and kindled audiogenic seizures
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DOI：
10.1016/s0378-5955(02)00371-4
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发表时间：
2002-06-01
期刊：
影响因子：
2.8
通讯作者：
Garcia-Cairasco, N
中科院分区：
文献类型：
--
作者：
Garcia-Cairasco, N
本文的主要目的是审查的关键作用，下丘在表达的声音运动和声学边缘系统整合参与，分别在急性和慢性听源性癫痫发作。为了把这一点的背景下，我们将审查的行为特征的急性和慢性听源性癫痫发作，神经解剖基板，神经化学，神经药理学，电生理学，以及参与其表达的细胞和分子机制。其次，我们也将我们的结果，收集从听源性癫痫易感大鼠，之前和之后的遗传选择我们自己的听源性易感菌株，并从那些致敏病变或药物显微注射，与那些相关的国际文献。简而言之，遗传或致敏动物在强直阵挛发作之前表现为一种狂野的奔跑行为。后者可以有几种表现，包括opistotonus和前肢和后肢强直性过伸，随后是前肢和后肢的阵挛性惊厥。慢性（点燃）听源性癫痫发作改变了这种行为表达，具有类似的模式，如颞叶癫痫发作中存在的模式，与原始的听源性癫痫发作模式混合，已知其依赖于脑干网络。(C)2002 Elsevier Science B.V.保留所有权利。
The main goal of this article is to review the key role that the inferior colliculus plays in the expression of acoustic-motor and acoustic-limbic integration involved, respectively, in acute and chronic audiogenic seizures. In order to put this in context, we will review the behavioral characterization of acute and chronic audiogenic seizures, neuroanatomical substrates, neurochemistry, neuropharmacology, electrophysiology, as well as the cellular and molecular mechanisms involved in their expression. Secondly, we will also correlate our results, collected from audiogenic seizures susceptible rats, before and after the genetic selection of our own audiogenic susceptible strain, and from those sensitized by lesions or drug microinjections, with those pertinent from the international literature. In brief, genetic or sensitized animals express acute audiogenic seizures as a wild running behavior preceding the onset of tonic-clonic seizures. The latter can have several presentations including opistotonus and fore- and hindlimb tonic hyperextensions, followed by clonic convulsions of fore- and hindlimbs. Chronic (kindled) audiogenic seizures change this behavioral expression, with similar patterns such as those present in temporal lobe epileptic seizures, intermingled with the original audiogenic seizure pattern, which is known to be dependent on brainstem networks. (C) 2002 Elsevier Science B.V. All rights reserved.