Patient-reported quality of life is associated with severity of chronic graft-versus-host disease as measured by NIH criteria: report on baseline data from the Chronic GVHD Consortium
Patient-reported quality of life is associated with severity of chronic graft-versus-host disease as measured by NIH criteria: report on baseline data from the Chronic GVHD Consortium
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DOI：
10.1182/blood-2010-11-319509
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发表时间：
2011-04-28
期刊：
影响因子：
20.3
通讯作者：
Lee, Stephanie J.
中科院分区：
文献类型：
--
作者：
Pidala, Joseph;Kurland, Brenda;Lee, Stephanie J.
慢性GVHD降低了造血细胞移植（HCT）后的生活质量（QOL）。在一项由慢性GVHD成人患者组成的前瞻性多中心队列研究中（n = 298），我们研究了美国国立卫生研究院（NIH）标准定义的慢性GVHD严重程度与入组时使用SF-36和FACT-BMT仪器测量的生活质量之间的关系。慢性GVHD严重程度与生活质量独立相关，随年龄调整。与人口标准数据相比，SF-36得分在总结身体成分得分（PCS）和角色身体分量表中平均降低了1个标准差（10分）以上，在其他几个分量表中显著降低（幅度为4-10分）。中度和重度cGVHD患者的PCS评分与系统性硬化症、系统性红斑狼疮和多发性硬化症的评分相当，与包括糖尿病、高血压和慢性肺病在内的常见慢性疾病相比，其损害更大。NIH标准定义的中度至重度cGVHD与多个生活质量域的显著损害相关，PCS评分在其他系统性自身免疫性疾病范围内。受损的生活质量提供了慢性GVHD影响的功能评估，并且可以在cGVHD临床研究中使用SF-36或FACT-BMT进行测量。(血。2011;117 (17):4651 - 4657)
Quality of life (QOL) after hematopoietic cell transplantation (HCT) is compromised by chronic GVHD. In a prospectively assembled multicenter cohort of adults with chronic GVHD (n = 298), we examined the relationship between chronic GVHD severity defined by National Institutes of Health (NIH) criteria and QOL as measured by the SF-36 and FACT-BMT instruments at time of enrollment. Chronic GVHD severity was independently associated with QOL, adjusting for age. Compared with population normative data, SF-36 scores were more than a SD (10 points) lower on average for the summary physical component score (PCS) and role-physical subscale, and significantly lower (with magnitude 4-10 points) for several other subscales. Patients with moderate and severe cGVHD had PCS scores comparable with scores reported for systemic sclerosis, systemic lupus erythematosus, and multiple sclerosis, and greater impairment compared with common chronic conditions including diabetes, hypertension, and chronic lung disease. Moderate to severe cGVHD as defined by NIH criteria is associated with significant compromise in multiple QOL domains, with PCS scores in the range of other systemic autoimmune diseases. Compromised QOL provides a functional assessment of the effects of chronic GVHD, and may be measured in cGVHD clinical studies using either the SF-36 or the FACT-BMT. (Blood. 2011;117(17):4651-4657)